| http://purl.uniprot.org/citations/18006747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18006747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18006747 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is constitutively expressed on cells of the innate immune system in both mice and humans, and that it can synergize with Toll-like receptors. Moreover, an antibody agonist of Tim-3 acted as an adjuvant during induced immune responses, and Tim-3 ligation induced distinct signaling events in T cells and dendritic cells; the latter finding could explain the apparent divergent functions of Tim-3 in these cell types. Thus, by virtue of differential expression on innate versus adaptive immune cells, Tim-3 can either promote or terminate TH1 immunity and may be able to influence a range of inflammatory conditions."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1148536"xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1148536"xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Anderson D.E."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Anderson D.E."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Lei C."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Lei C."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Anderson A.C."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Anderson A.C."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Kane L.P."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Kane L.P."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Hirashima M."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Hirashima M."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Kassam N."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Kassam N."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Bregoli L."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Bregoli L."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Hafler D.A."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Hafler D.A."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Bruce J.N."xsd:string |
| http://purl.uniprot.org/citations/18006747 | http://purl.uniprot.org/core/author | "Bruce J.N."xsd:string |