| http://purl.uniprot.org/citations/18007658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18007658 | http://www.w3.org/2000/01/rdf-schema#comment | "Endoplasmic reticulum (ER)-associated degradation (ERAD) is a specialized activity of the ubiquitin-proteasome system that is involved in clearing the ER of aberrant proteins and regulating the levels of specific ER-resident proteins. Here we show that the yeast ER-SNARE Ufe1, a syntaxin (Qa-SNARE) involved in ER membrane fusion and retrograde transport from the Golgi to the ER, is prone to degradation by an ERAD-like mechanism. Notably, Ufe1 is protected against degradation through binding to Sly1, a known SNARE regulator of the Sec1-Munc18 (SM) protein family. This mechanism is specific for Ufe1, as the stability of another Sly1 partner, the Golgi Qa-SNARE Sed5, is not influenced by Sly1 interaction. Thus, our findings identify Sly1 as a discriminating regulator of SNARE levels and indicate that Sly1-controlled ERAD might regulate the balance between different Qa-SNARE proteins."xsd:string |
| http://purl.uniprot.org/citations/18007658 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7401105"xsd:string |
| http://purl.uniprot.org/citations/18007658 | http://purl.uniprot.org/core/author | "Jentsch S."xsd:string |
| http://purl.uniprot.org/citations/18007658 | http://purl.uniprot.org/core/author | "Braun S."xsd:string |
| http://purl.uniprot.org/citations/18007658 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18007658 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/18007658 | http://purl.uniprot.org/core/pages | "1176-1182"xsd:string |
| http://purl.uniprot.org/citations/18007658 | http://purl.uniprot.org/core/title | "SM-protein-controlled ER-associated degradation discriminates between different SNAREs."xsd:string |
| http://purl.uniprot.org/citations/18007658 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/18007658 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18007658 |
| http://purl.uniprot.org/citations/18007658 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18007658 |
| http://purl.uniprot.org/uniprot/#_A0A8H4F7E7-mappedCitation-18007658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18007658 |
| http://purl.uniprot.org/uniprot/#_A0A6A5PR90-mappedCitation-18007658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18007658 |
| http://purl.uniprot.org/uniprot/#_A0A8H8UN98-mappedCitation-18007658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18007658 |
| http://purl.uniprot.org/uniprot/#_P41834-mappedCitation-18007658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18007658 |
| http://purl.uniprot.org/uniprot/#_P22213-mappedCitation-18007658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18007658 |
| http://purl.uniprot.org/uniprot/#_Q01590-mappedCitation-18007658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18007658 |
| http://purl.uniprot.org/uniprot/A0A6A5PR90 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18007658 |
| http://purl.uniprot.org/uniprot/Q01590 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18007658 |
| http://purl.uniprot.org/uniprot/P41834 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18007658 |
| http://purl.uniprot.org/uniprot/A0A8H8UN98 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18007658 |
| http://purl.uniprot.org/uniprot/P22213 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18007658 |
| http://purl.uniprot.org/uniprot/A0A8H4F7E7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18007658 |