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http://purl.uniprot.org/citations/18021874http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18021874http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Our aim was to determine if a high-performance assay for heart-type fatty acid-binding protein (H-FABP) has a role in predicting all-cause mortality after acute coronary syndrome (ACS).

Background

Heart-type fatty acid-binding protein is released into the circulation following myocardial ischemia and necrosis and therefore may be of value to physicians when caring for patients admitted to hospital with a clinical diagnosis of ACS.

Methods

This was a prospective observational study with a follow-up of 12 months. The H-FABP was measured 12 to 24 h after onset of symptoms in 1,448 patients admitted to hospital with ACS. The main outcome measure was all-cause mortality 1 year after index hospital admission. Multivariable analyses were conducted using the well validated GRACE (Global Registry of Acute Coronary Events) variables together with troponin I and highly sensitive C-reactive protein (hs-CRP).

Results

After 12 months of follow-up, 296 patients had died. Multivariable analysis demonstrated that H-FABP quartiles were strongly predictive of outcome: Q1 hazard ratio (HR) 1.0; Q2 HR 2.32 (95% confidence interval [CI] 1.25 to 4.30; p = 0.007); Q3 HR 3.17 (95% CI 1.73 to 5.82; p < 0.001); Q4 HR 4.88 (95% CI 2.67 to 8.93; p < 0.001). The crude all-cause 1-year mortality for unstable angina patients with H-FABP <5.8 microg/l was 2.1% compared with 22.9% for patients above this cutoff. The adjusted all-cause mortality HR in this group was 11.35 (95% CI 2.00 to 64.34; p = 0.006).

Conclusions

Heart-type fatty acid-binding protein predicts long-term mortality after ACS and identifies high-risk patients in a manner that is additive to the GRACE clinical risk factors, troponin, and hs-CRP, possibly as a result of identifying the occurrence of myocardial ischemia with or without necrosis."xsd:string
http://purl.uniprot.org/citations/18021874http://purl.org/dc/terms/identifier"doi:10.1016/j.jacc.2007.08.021"xsd:string
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/author"Das R."xsd:string
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/author"Hall A.S."xsd:string
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/author"Viswanathan K."xsd:string
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/author"Morrell C."xsd:string
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/author"Barth J.H."xsd:string
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/author"Farrin A."xsd:string
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/author"Kilcullen N."xsd:string
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/name"J Am Coll Cardiol"xsd:string
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/pages"2061-2067"xsd:string
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/title"Heart-type fatty acid-binding protein predicts long-term mortality after acute coronary syndrome and identifies high-risk patients across the range of troponin values."xsd:string
http://purl.uniprot.org/citations/18021874http://purl.uniprot.org/core/volume"50"xsd:string
http://purl.uniprot.org/citations/18021874http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18021874
http://purl.uniprot.org/citations/18021874http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18021874
http://purl.uniprot.org/uniprot/#_A0A384MDY5-mappedCitation-18021874http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18021874
http://purl.uniprot.org/uniprot/#_P05413-mappedCitation-18021874http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18021874
http://purl.uniprot.org/uniprot/#_Q6IBD7-mappedCitation-18021874http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18021874
http://purl.uniprot.org/uniprot/A0A384MDY5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18021874
http://purl.uniprot.org/uniprot/P05413http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18021874
http://purl.uniprot.org/uniprot/Q6IBD7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18021874