| http://purl.uniprot.org/citations/18022237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18022237 | http://www.w3.org/2000/01/rdf-schema#comment | "Early T lineage cells are selected in the thymus by the specific recognition of peptide components presented by MHC molecules on the surface of thymic epithelial cells and dendritic cells. As a potential regulator of the apoptotic and survival signals, the protein phosphatase 2A-component G5PR regulates Bim phosphorylation in B-cells. Here, we studied whether G5PR is involved in the regulation of the similar apoptotic pathway for cell survival during the selection of thymocytes. T-cell-specific G5PR knockout (G5pr(-/-)) mice displayed thymic atrophy, significant reduction in thymocyte numbers, particularly a 10-fold decrease in the number of CD4 and CD8 double-positive (DP) thymocytes and few mature single-positive (SP) cells. G5pr(-/-) thymocytes exhibited normal potential of proliferation and differentiation during the transition from double-negative (DN) to DP stage, but significantly increased susceptibility to apoptosis at the DP stage. G5PR deficiency did not affect on Bim activation in thymocytes, but caused hyper-activation of JNK and Caspase-3 with augmented Fas ligand (FasL) expression, indicating that G5PR regulates the thymocyte unique apoptotic signal involved in JNK-mediated Caspase-3 activation but not in Bim activation. G5PR is essential for the survival of DP cells during thymocyte development."xsd:string |
| http://purl.uniprot.org/citations/18022237 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2007.10.028"xsd:string |
| http://purl.uniprot.org/citations/18022237 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/18022237 | http://purl.uniprot.org/core/author | "Sakaguchi N."xsd:string |
| http://purl.uniprot.org/citations/18022237 | http://purl.uniprot.org/core/author | "Xing Y."xsd:string |
| http://purl.uniprot.org/citations/18022237 | http://purl.uniprot.org/core/author | "Igarashi H."xsd:string |
| http://purl.uniprot.org/citations/18022237 | http://purl.uniprot.org/core/author | "Kawamoto H."xsd:string |
| http://purl.uniprot.org/citations/18022237 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18022237 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/18022237 | http://purl.uniprot.org/core/pages | "2028-2037"xsd:string |
| http://purl.uniprot.org/citations/18022237 | http://purl.uniprot.org/core/title | "Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes."xsd:string |
| http://purl.uniprot.org/citations/18022237 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/18022237 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18022237 |
| http://purl.uniprot.org/citations/18022237 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18022237 |
| http://purl.uniprot.org/uniprot/#_D3Z1Z4-mappedCitation-18022237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18022237 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPL3-mappedCitation-18022237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18022237 |
| http://purl.uniprot.org/uniprot/#_A3KBF5-mappedCitation-18022237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18022237 |
| http://purl.uniprot.org/uniprot/#_A6P3E4-mappedCitation-18022237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18022237 |
| http://purl.uniprot.org/uniprot/#_G3X8U9-mappedCitation-18022237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18022237 |
| http://purl.uniprot.org/uniprot/#_Q544A0-mappedCitation-18022237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18022237 |
| http://purl.uniprot.org/uniprot/#_Q9JK24-mappedCitation-18022237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18022237 |
| http://purl.uniprot.org/uniprot/#_Q7TSJ7-mappedCitation-18022237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18022237 |
| http://purl.uniprot.org/uniprot/#_Q91Y86-mappedCitation-18022237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18022237 |
| http://purl.uniprot.org/uniprot/D3Z1Z4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18022237 |