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http://purl.uniprot.org/citations/18022727http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18022727http://www.w3.org/2000/01/rdf-schema#comment"

Background/aims

The risk of developing autoimmune hepatitis (AIH) has been suggested to be associated with the presence of HLA-DRB1 alleles encoding the 'shared epitope' at amino acid positions 67-72 in the third hypervariable region (HVR3) of DRbeta. We aimed to identify the specific HLA alleles that are susceptible to type 1 AIH in Koreans, and to validate the shared epitope hypothesis in this single ethnic group.

Methods

Sixty-two adult patients with definite type 1 AIH and 154 healthy controls were enrolled. Alleles of HLA class I and II genes were genotyped using sequence-based typing.

Results

By high-resolution analysis, the frequencies of DRB1 *0405 and DQB1 *0401 were significantly increased in patients with AIH (P = 0.0001, OR = 3.74; P = 0.00006, OR = 3.95, respectively). The six amino acid motif represented by the single letter code LLEQRR or LLEQKR at positions 67-72 of the DRbeta polypeptide was not sufficient to show an increased risk for the disease. Interestingly, the QRRAA motif at positions 70-74 was significantly increased in Korean patients (P=0.04, OR=1.84).

Conclusions

The shared epitope hypothesis may be extended to the amino acid motif at positions 70-74 of HLA-DRbeta in order to better predict the susceptibility to type 1 AIH."xsd:string
http://purl.uniprot.org/citations/18022727http://purl.org/dc/terms/identifier"doi:10.1016/j.jhep.2007.08.019"xsd:string
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/author"Oh H.B."xsd:string
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/author"Lim Y.S."xsd:string
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/author"Lee H.C."xsd:string
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/author"Heo Y.S."xsd:string
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/author"Choi S.E."xsd:string
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/author"Kwon O.J."xsd:string
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/author"Suh D.J."xsd:string
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/name"J Hepatol"xsd:string
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/pages"133-139"xsd:string
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/title"Susceptibility to type 1 autoimmune hepatitis is associated with shared amino acid sequences at positions 70-74 of the HLA-DRB1 molecule."xsd:string
http://purl.uniprot.org/citations/18022727http://purl.uniprot.org/core/volume"48"xsd:string
http://purl.uniprot.org/citations/18022727http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18022727
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