Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/18023033http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18023033http://www.w3.org/2000/01/rdf-schema#comment"

Background

Nasopharyngeal carcinoma (NPC) is associated with Epstein-Barr virus (EBV) and has high metastatic potential. Discoidin domain receptors (DDR1, DDR2) are receptor-type tyrosine kinases activated by collagen. Their ability to induce expression of matrix metalloproteinase is related with tumor invasion. Therefore, we aim to investigate DDRs gene expression and its regulation in NPC.

Methods and results

By use of real-time quantitative polymerase chain reaction (Q-PCR), DDR2 gene expression but not DDR1 was significantly higher in primary and metastatic NPC. DDR2 was predominantly distributed in NPC tumor cells rather than in infiltrating lymphocytes. EBV Z-transactivator (Zta) transfection may distinctly elevate DDR2 level. Furthermore, data from reporter assay indicate that Zta could transactivate DDR2 promoter activity, suggesting the possible upregulation mechanism.

Conclusion

DDR2 was differentially upregulated in NPC and modulated by EBV Zta protein. DDR2 may play a role in NPC invasion and serve as a diagnostic and therapeutic target."xsd:string
http://purl.uniprot.org/citations/18023033http://purl.org/dc/terms/identifier"doi:10.1002/hed.20724"xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/author"Huang Y.T."xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/author"Tsai C.H."xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/author"Sheen T.S."xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/author"Wang Y.P."xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/author"Chou Y.C."xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/author"Yeh T.H."xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/author"Lo Y.C."xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/author"Chua H.H."xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/name"Head Neck"xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/pages"427-436"xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/title"Upregulation of discoidin domain receptor 2 in nasopharyngeal carcinoma."xsd:string
http://purl.uniprot.org/citations/18023033http://purl.uniprot.org/core/volume"30"xsd:string
http://purl.uniprot.org/citations/18023033http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18023033
http://purl.uniprot.org/citations/18023033http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18023033
http://purl.uniprot.org/uniprot/#_A0A0A0MSX3-mappedCitation-18023033http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18023033
http://purl.uniprot.org/uniprot/#_A0A024RCQ1-mappedCitation-18023033http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18023033
http://purl.uniprot.org/uniprot/#_A0A1U9X7K3-mappedCitation-18023033http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18023033
http://purl.uniprot.org/uniprot/#_A0A1U9X7L5-mappedCitation-18023033http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18023033
http://purl.uniprot.org/uniprot/#_A0A1U9X7M1-mappedCitation-18023033http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18023033
http://purl.uniprot.org/uniprot/#_B7Z3A2-mappedCitation-18023033http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18023033
http://purl.uniprot.org/uniprot/#_Q08345-mappedCitation-18023033http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18023033
▶