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| http://purl.uniprot.org/citations/18023270 | http://www.w3.org/2000/01/rdf-schema#comment | "The effects of ceramides (Cer) on the trafficking of the nicotinic acetylcholine receptor (AChR) to the plasma membrane were studied in CHO-K1/A5 cells, a clonal cell line that heterologously expresses the adult murine form of the receptor. When cells were incubated with short- (C6-Cer) or long-(brain-Cer) chain Cer at low concentrations, an increase in the number of cell-surface AChRs was observed concomitant with a decrease in intracellular receptor levels. The alteration in AChR distribution by low Cer treatment does not appear to be a general mechanism since the surface expression of the green fluorescent protein derivative of the vesicular stomatitis virus protein (VSVG-GFP) was not affected. High Cer concentrations caused the opposite effects, decreasing the number of cell-surface AChRs, which exhibited higher affinity for [125I]-alpha-bungarotoxin, and increasing the intracellular pool, which colocalized with trans-Golgi/TGN specific markers. The generation of endogenous Cer by sphingomyelinase treatment also decreased cell-surface AChR levels. These effects do not involve protein kinase C zeta or protein phosphatase 2A activation. Taken together, the results indicate that Cer modulate trafficking of AChRs to and stability at the cell surface."xsd:string |
| http://purl.uniprot.org/citations/18023270 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamem.2007.10.019"xsd:string |
| http://purl.uniprot.org/citations/18023270 | http://purl.uniprot.org/core/author | "Barrantes F.J."xsd:string |
| http://purl.uniprot.org/citations/18023270 | http://purl.uniprot.org/core/author | "Gallegos C.E."xsd:string |
| http://purl.uniprot.org/citations/18023270 | http://purl.uniprot.org/core/author | "Pediconi M.F."xsd:string |
| http://purl.uniprot.org/citations/18023270 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18023270 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/18023270 | http://purl.uniprot.org/core/pages | "917-930"xsd:string |
| http://purl.uniprot.org/citations/18023270 | http://purl.uniprot.org/core/title | "Ceramides modulate cell-surface acetylcholine receptor levels."xsd:string |
| http://purl.uniprot.org/citations/18023270 | http://purl.uniprot.org/core/volume | "1778"xsd:string |
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