| http://purl.uniprot.org/citations/18024321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18024321 | http://www.w3.org/2000/01/rdf-schema#comment | "We studied the prognostic importance of tumor-infiltrating regulatory T lymphocytes (Tregs) and cytotoxic T/NK lymphocytes (CTLs) in 98 diagnostic biopsy specimens from patients with classical Hodgkin lymphoma (cHL). Immunohistochemical analysis was performed for FOXP3 to identify Tregs and for granzyme B (GrB) to identify activated CTLs. Failure-free survival (FFS) and overall survival (OS) were clinical end points. Patients with fewer than 25 FOXP3+ cells per high-power field (HPF) had a mean +/- SD 5-year FFS of 64% +/-7% vs 85% +/-5% for patients with 25 or more FOXP3+ cells/HPF (P = .05). A FOXP3/GrB ratio of 1 or less was associated with poor FFS (46% +/- 10% vs 86% +/-4%; P < .001) and OS (67% +/- 10% vs 93% +/-3%; P < .001). When prior available MAL and bcl-2 expression data were included in a multivariate analysis of all clinical and biologic factors, a FOXP3/GrB ratio of 1 or less and tumor cell expression of MAL and bcl-2 all independently predicted poor FFS. This demonstrates the importance of evaluating tumor cell markers and the tumor immune infiltrate when considering biologic prognostic markers in cHL."xsd:string |
| http://purl.uniprot.org/citations/18024321 | http://purl.org/dc/terms/identifier | "doi:10.1309/nb3947k383dj0lq2"xsd:string |
| http://purl.uniprot.org/citations/18024321 | http://purl.uniprot.org/core/author | "Hsi E.D."xsd:string |
| http://purl.uniprot.org/citations/18024321 | http://purl.uniprot.org/core/author | "Kelley T.W."xsd:string |
| http://purl.uniprot.org/citations/18024321 | http://purl.uniprot.org/core/author | "Elson P."xsd:string |
| http://purl.uniprot.org/citations/18024321 | http://purl.uniprot.org/core/author | "Pohlman B."xsd:string |
| http://purl.uniprot.org/citations/18024321 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18024321 | http://purl.uniprot.org/core/name | "Am J Clin Pathol"xsd:string |
| http://purl.uniprot.org/citations/18024321 | http://purl.uniprot.org/core/pages | "958-965"xsd:string |
| http://purl.uniprot.org/citations/18024321 | http://purl.uniprot.org/core/title | "The ratio of FOXP3+ regulatory T cells to granzyme B+ cytotoxic T/NK cells predicts prognosis in classical Hodgkin lymphoma and is independent of bcl-2 and MAL expression."xsd:string |
| http://purl.uniprot.org/citations/18024321 | http://purl.uniprot.org/core/volume | "128"xsd:string |
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