| http://purl.uniprot.org/citations/18025456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18025456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18025456 | http://www.w3.org/2000/01/rdf-schema#comment | "How are the rates of aging of different tissues coordinated? In Caenorhabditis elegans, decreasing insulin/IGF-1 signaling extends lifespan by activating the transcription factor DAF-16/FOXO. If DAF-16 levels are experimentally increased in one tissue, such as the intestine, DAF-16 activity in other tissues rises. Here we test the hypothesis that this "FOXO-to-FOXO" signaling occurs via feedback regulation of ins-7 insulin gene expression. We find that DAF-16 regulates ins-7 expression in the intestine, and that preventing this regulation blocks FOXO-to-FOXO signaling from the intestine to other tissues. Our findings show that feedback regulation of insulin gene expression coordinates DAF-16 activity among the tissues, and they establish the intestine, which is the animal's entire endoderm, as an important insulin-signaling center."xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0709613104"xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0709613104"xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/author | "Murphy C.T."xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/author | "Murphy C.T."xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/author | "Kenyon C."xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/author | "Kenyon C."xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/pages | "19046-19050"xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/pages | "19046-19050"xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/title | "Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/title | "Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/18025456 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18025456 |
| http://purl.uniprot.org/citations/18025456 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18025456 |
| http://purl.uniprot.org/citations/18025456 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18025456 |
| http://purl.uniprot.org/citations/18025456 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18025456 |