| http://purl.uniprot.org/citations/18025560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18025560 | http://www.w3.org/2000/01/rdf-schema#comment | "Fructose-1,6-bisphosphate (F-1,6-P2) is an allosteric activator of two key enzymes of glycolysis: phosphofructokinase and pyruvate kinase. Regulation of glycolysis in a wild-type Saccharomyces cerevisiae and a recombinant Escherichia coli by a dead-end structural analog of F-1,6-P2 was studied. 2,5-Anhydromannitol (2,5-AM), a structural analog of beta-d-fructose, was used. On being taken up by the cells, 2,5-AM was converted into its monophosphate and diphosphate by the enzymes of the glycolytic pathway. The final product, 2,5-anhydromannitol-1,6-bisphosphate, could not be metabolized further and, therefore, accumulated inside the cells. Glucose and fructose were used as substrates. It was found that 2,5-AM at concentrations of 1 mM or less did not have any effect on either substrate consumption or ethanol production. At concentrations of 2,5-AM of 2.5 mM or greater, significant inhibition of both glucose and fructose was observed, with fructose inhibition much more severe. We discuss the possible mechanisms of glycolysis inhibition by 2,5-AM at high concentrations and the regulation of glycolysis by this compound."xsd:string |
| http://purl.uniprot.org/citations/18025560 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf02729071"xsd:string |
| http://purl.uniprot.org/citations/18025560 | http://purl.uniprot.org/core/author | "Cofer T.M."xsd:string |
| http://purl.uniprot.org/citations/18025560 | http://purl.uniprot.org/core/author | "Nghiem N.P."xsd:string |
| http://purl.uniprot.org/citations/18025560 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18025560 | http://purl.uniprot.org/core/name | "Appl Biochem Biotechnol"xsd:string |
| http://purl.uniprot.org/citations/18025560 | http://purl.uniprot.org/core/pages | "335-347"xsd:string |
| http://purl.uniprot.org/citations/18025560 | http://purl.uniprot.org/core/title | "Effect of a nonmetabolizable analog of fructose-1,6-bisphosphate on glycolysis and ethanol production in strains of Saccharomyces cerevisiae and Escherichia coli."xsd:string |
| http://purl.uniprot.org/citations/18025560 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/18025560 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18025560 |
| http://purl.uniprot.org/citations/18025560 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18025560 |
| http://purl.uniprot.org/uniprot/#_P52489-mappedCitation-18025560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18025560 |
| http://purl.uniprot.org/uniprot/#_P16861-mappedCitation-18025560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18025560 |
| http://purl.uniprot.org/uniprot/#_P16862-mappedCitation-18025560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18025560 |
| http://purl.uniprot.org/uniprot/P16862 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18025560 |
| http://purl.uniprot.org/uniprot/P16861 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18025560 |
| http://purl.uniprot.org/uniprot/P52489 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18025560 |