| http://purl.uniprot.org/citations/18026113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18026113 | http://www.w3.org/2000/01/rdf-schema#comment | "A successful pregnancy requires synchronized adaptation of maternal immune-endocrine mechanisms to the fetus. Here we show that galectin-1 (Gal-1), an immunoregulatory glycan-binding protein, has a pivotal role in conferring fetomaternal tolerance. Consistently with a marked decrease in Gal-1 expression during failing pregnancies, Gal-1-deficient (Lgals1-/-) mice showed higher rates of fetal loss compared to wild-type mice in allogeneic matings, whereas fetal survival was unaffected in syngeneic matings. Treatment with recombinant Gal-1 prevented fetal loss and restored tolerance through multiple mechanisms, including the induction of tolerogenic dendritic cells, which in turn promoted the expansion of interleukin-10 (IL-10)-secreting regulatory T cells in vivo. Accordingly, Gal-1's protective effects were abrogated in mice depleted of regulatory T cells or deficient in IL-10. In addition, we provide evidence for synergy between Gal-1 and progesterone in the maintenance of pregnancy. Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm1680"xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Garcia M."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Tirado I."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Blois S.M."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Klapp B.F."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Poirier F."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Rabinovich G.A."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Markert U.R."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Szekeres-Bartho J."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Kobelt P."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Arck P.C."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Handjiski B."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Tometten M."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Ilarregui J.M."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Toscano M.A."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Bianco G.A."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Orsal A.S."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/author | "Cordo-Russo R."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/pages | "1450-1457"xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/title | "A pivotal role for galectin-1 in fetomaternal tolerance."xsd:string |
| http://purl.uniprot.org/citations/18026113 | http://purl.uniprot.org/core/volume | "13"xsd:string |