| http://purl.uniprot.org/citations/18028904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18028904 | http://www.w3.org/2000/01/rdf-schema#comment | "Dictyostelium discoideum expresses multiple G alpha subunits but only a single G beta and G gamma subunit suggesting that the specific response to an external signal depends largely on G alpha subunit function or G protein-independent signaling from the receptor. To test the contribution of G alpha subunit functional specificity, the chimeric G alpha subunits, G alpha2/4 and G alpha5/4, were created and analyzed along with wild-type subunits for the ability to substitute for the G alpha4 subunit in mediating responses from folate receptors. The G alpha2/4 subunit, but not the G alpha2 or G alpha5/4 subunits, partly rescued chemotaxis and cGMP accumulation in folate-stimulated g alpha4(-) cells. Expression of the G alpha5/4 or G alpha5 subunits resulted in an inhibition of g alpha4- and wild-type cell movement and a reduced aggregate size in developing wild-type and g alpha5-cells suggesting these subunits mediate similar responses. Only the G alpha4 subunit was capable of correcting developmental morphology in g alpha4-multicellular aggregates suggesting that the chimeric G alpha2/4 or G alpha5/4 subunits were insufficient to provide the G alpha4 function necessary for proper development. These results indicate that Dictyostelium G alpha subunit specificity is not limited to receptor coupling and that G alpha subunit sequences outside of the carboxyl terminus are important for cell movement and developmental processes."xsd:string |
| http://purl.uniprot.org/citations/18028904 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2007.08.017"xsd:string |
| http://purl.uniprot.org/citations/18028904 | http://purl.uniprot.org/core/author | "Hadwiger J.A."xsd:string |
| http://purl.uniprot.org/citations/18028904 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18028904 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/18028904 | http://purl.uniprot.org/core/pages | "1-12"xsd:string |
| http://purl.uniprot.org/citations/18028904 | http://purl.uniprot.org/core/title | "Developmental morphology and chemotactic responses are dependent on G alpha subunit specificity in Dictyostelium."xsd:string |
| http://purl.uniprot.org/citations/18028904 | http://purl.uniprot.org/core/volume | "312"xsd:string |
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