DESCRIBE <http://purl.uniprot.org/citations/18033806>

Subject	Predicate	Object
http://purl.uniprot.org/citations/18033806	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18033806	http://www.w3.org/2000/01/rdf-schema#comment	" Background The stage of folliculogenesis at which the human zona pellucida (ZP) is initiated and the cells responsible for the origin of the ZP continue to be controversial. This study characterizes the development of the ZP during human folliculogenesis using ovarian samples donated from patients requesting ovarian storage. Methods Follicles (from n = 18 patients, 14-40 years old) within fresh tissue and following development in a xenograft system were stained, using immunohistochemical techniques, for the presence of the three human ZP proteins, ZP1, ZP2 and ZP3. Over 500 primordial follicles and >20 follicles at each developmental stage were examined. Results All three ZP proteins were detected within the oocyte of the primordial follicle. Presence of ZP1 and ZP3 was observed in the majority of primordial oocytes (93% and 95%, respectively), whereas ZP2 was detected in only 32% of these follicles. The three ZP proteins were detected in the cytoplasm of cuboidal granulosa cells and their distribution correlates with developmental stages throughout folliculogenesis. Conclusions ZP proteins were detected in both the oocyte and the granulosa cells as early as the primordial follicle stage in the human. The detection of ZP proteins in the quiescent primordial follicle suggests that these proteins have been present since oogenesis."xsd:string
http://purl.uniprot.org/citations/18033806	http://purl.org/dc/terms/identifier	"doi:10.1093/humrep/dem373"xsd:string
http://purl.uniprot.org/citations/18033806	http://purl.uniprot.org/core/author	"Borg J."xsd:string
http://purl.uniprot.org/citations/18033806	http://purl.uniprot.org/core/author	"Edgar D.H."xsd:string
http://purl.uniprot.org/citations/18033806	http://purl.uniprot.org/core/author	"Gook D.A."xsd:string
http://purl.uniprot.org/citations/18033806	http://purl.uniprot.org/core/author	"Martic M."xsd:string
http://purl.uniprot.org/citations/18033806	http://purl.uniprot.org/core/date	"2008"xsd:gYear
http://purl.uniprot.org/citations/18033806	http://purl.uniprot.org/core/name	"Hum Reprod"xsd:string
http://purl.uniprot.org/citations/18033806	http://purl.uniprot.org/core/pages	"394-402"xsd:string
http://purl.uniprot.org/citations/18033806	http://purl.uniprot.org/core/title	"Detection of zona pellucida proteins during human folliculogenesis."xsd:string
http://purl.uniprot.org/citations/18033806	http://purl.uniprot.org/core/volume	"23"xsd:string
http://purl.uniprot.org/citations/18033806	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/18033806
http://purl.uniprot.org/citations/18033806	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/18033806
http://purl.uniprot.org/uniprot/#_A0A023ZYH6-mappedCitation-18033806	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18033806
http://purl.uniprot.org/uniprot/#_P21754-mappedCitation-18033806	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18033806
http://purl.uniprot.org/uniprot/#_Q2XN66-mappedCitation-18033806	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18033806
http://purl.uniprot.org/uniprot/#_P60852-mappedCitation-18033806	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18033806
http://purl.uniprot.org/uniprot/#_Q6NVU7-mappedCitation-18033806	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18033806
http://purl.uniprot.org/uniprot/#_V9HWI9-mappedCitation-18033806	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18033806
http://purl.uniprot.org/uniprot/P21754	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/18033806
http://purl.uniprot.org/uniprot/A0A023ZYH6	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/18033806
http://purl.uniprot.org/uniprot/Q6NVU7	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/18033806
http://purl.uniprot.org/uniprot/P60852	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/18033806
http://purl.uniprot.org/uniprot/V9HWI9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/18033806