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http://purl.uniprot.org/citations/18034455http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18034455http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18034455http://www.w3.org/2000/01/rdf-schema#comment"Metazoans employ reversible tyrosine phosphorylation to regulate innumerable biological processes. Thus, the large-scale identification of tyrosine phosphorylation sites from primary tissues is an essential step toward a molecular systems understanding of dynamic regulation in vivo. The relative paucity of phosphotyrosine has greatly limited its identification in large-scale phosphoproteomic experiments. However, using antiphosphotyrosine peptide immunoprecipitations, we report the largest study to date of tyrosine phosphorylation sites from primary tissue, identifying 414 unique tyrosine phosphorylation sites from murine brain. To measure the conservation of phosphorylated tyrosines and their surrounding residues, we constructed a computational pipeline and identified patterns of conservation within the signature of phosphotyrosine."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.org/dc/terms/identifier"doi:10.1021/pr0701254"xsd:string
http://purl.uniprot.org/citations/18034455http://purl.org/dc/terms/identifier"doi:10.1021/pr0701254"xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/author"Ballif B.A."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/author"Ballif B.A."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/author"Carey G.R."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/author"Carey G.R."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/author"Gygi S.P."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/author"Gygi S.P."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/author"Sunyaev S.R."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/author"Sunyaev S.R."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/name"J. Proteome Res."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/name"J. Proteome Res."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/pages"311-318"xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/pages"311-318"xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/title"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/title"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/volume"7"xsd:string
http://purl.uniprot.org/citations/18034455http://purl.uniprot.org/core/volume"7"xsd:string
http://purl.uniprot.org/citations/18034455http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18034455
http://purl.uniprot.org/citations/18034455http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18034455