| http://purl.uniprot.org/citations/18035379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18035379 | http://www.w3.org/2000/01/rdf-schema#comment | "The influence of low-activity NER genotypes (XPC PAT-/+, XPA-A23G, XPD Asp312Asn, XPD Lys751Gln) and GSTM1 (active or null) was evaluated on anti-benzo[a]pyrene diol epoxide-(B[a]PDE)-DNA adduct formed in the lymphocyte plus monocyte fraction (LMF). The sample population consisted of 291 healthy subjects with low exposure to polycyclic aromatic hydrocarbons (PAHs) (B[a]P) through their smoking (n=126 smokers) or dietary habits (n=165 non-smokers with high (>or=52 times/year) consumption of charcoaled meat or pizza). The bulky anti-B[a]PDE-DNA adduct levels were detected by HPLC/fluorescence analysis and genotypes by PCR. Anti-B[a]PDE-DNA was present (>or=0.5 adducts/10(8) nucleotides) in 163 (56%) subjects (median (range) 0.77 (0.125-32.0) adducts/10(8) nucleotides), with smokers showing a significantly higher adduct level than non-smokers with high consumption of PAH-rich meals (P<0.01). Our exposed-sample population with unfavourable XPC PAT+/- or +/+ and GSTM1 null genotypes has the significantly highest adduct level (P<0.01). Taking into account tobacco smoke and diet as sources of exposure to B[a]P, low-activity XPC PAT+ shows a major role in smokers (P<0.05) and GSTM1 null in non-smokers with frequent consumption of PAH-rich meals (P<0.01). The modulation of anti-B[a]PDE-DNA adduct in the LMF by GSTM1 null and low-activity XPC PAT+ polymorphisms may be considered as potential genetic susceptibility factors that can modify individual responses to low PAH (B[a]P) genotoxic exposure, with the consequent risk of cancer in the general population."xsd:string |
| http://purl.uniprot.org/citations/18035379 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mrfmmm.2007.10.004"xsd:string |
| http://purl.uniprot.org/citations/18035379 | http://purl.uniprot.org/core/author | "Pavanello S."xsd:string |
| http://purl.uniprot.org/citations/18035379 | http://purl.uniprot.org/core/author | "Clonfero E."xsd:string |
| http://purl.uniprot.org/citations/18035379 | http://purl.uniprot.org/core/author | "Pulliero A."xsd:string |
| http://purl.uniprot.org/citations/18035379 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18035379 | http://purl.uniprot.org/core/name | "Mutat Res"xsd:string |
| http://purl.uniprot.org/citations/18035379 | http://purl.uniprot.org/core/pages | "195-204"xsd:string |
| http://purl.uniprot.org/citations/18035379 | http://purl.uniprot.org/core/title | "Influence of GSTM1 null and low repair XPC PAT+ on anti-B[a]PDE-DNA adduct in mononuclear white blood cells of subjects low exposed to PAHs through smoking and diet."xsd:string |
| http://purl.uniprot.org/citations/18035379 | http://purl.uniprot.org/core/volume | "638"xsd:string |
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