| http://purl.uniprot.org/citations/18037992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18037992 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia has been proposed as an important microenvironmental factor in the development of tissue fibrosis; however, the underlying mechanisms are not well defined. To examine the role of hypoxia-inducible factor-1 (HIF-1), a key mediator of cellular adaptation to hypoxia, in the development of fibrosis in mice, we inactivated Hif-1alpha in primary renal epithelial cells and in proximal tubules of kidneys subjected to unilateral ureteral obstruction (UUO) using Cre-loxP-mediated gene targeting. We found that Hif-1alpha enhanced epithelial-to-mesenchymal transition (EMT) in vitro and induced epithelial cell migration through upregulation of lysyl oxidase genes. Genetic ablation of epithelial Hif-1alpha inhibited the development of tubulointerstitial fibrosis in UUO kidneys, which was associated with decreased interstitial collagen deposition, decreased inflammatory cell infiltration, and a reduction in the number of fibroblast-specific protein-1-expressing (FSP-1-expressing) interstitial cells. Furthermore, we demonstrate that increased renal HIF-1alpha expression is associated with tubulointerstitial injury in patients with chronic kidney disease. Thus, we provide clinical and genetic evidence that activation of HIF-1 signaling in renal epithelial cells is associated with the development of chronic renal disease and may promote fibrogenesis by increasing expression of extracellular matrix-modifying factors and lysyl oxidase genes and by facilitating EMT."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci30487"xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Kimura K."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Saito Y."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Johnson R.S."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Iwano M."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Hohenstein B."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Cohen C.D."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Kretzler M."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Haase V.H."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Eckardt K.U."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Akai Y."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Higgins D.F."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Shrimanker N."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/author | "Bernhardt W.M."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/pages | "3810-3820"xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/title | "Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition."xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/18037992 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18037992 |
| http://purl.uniprot.org/citations/18037992 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18037992 |
| http://purl.uniprot.org/uniprot/Q16665#attribution-F182D3BB1FFBB2570DAD7C2258AEF167 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18037992 |
| http://purl.uniprot.org/uniprot/Q61221#attribution-D81CB47B87BC6472281E8FA7C70812BA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18037992 |