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http://purl.uniprot.org/citations/18038108http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18038108http://www.w3.org/2000/01/rdf-schema#comment"

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Here we report the results of a vitamin D-binding protein gene microsatellite polymorphism study in 170 men, comprising healthy male subjects and men with osteoporosis-related symptomatic vertebral fractures. We confirm the results of an earlier study in a different cohort, showing relationship between certain genotypes of (TAAAn)-Alu repeats and reduced BMD and vertebral fractures.

Introduction

Vitamin D-binding protein (DBP) plays a critical role in the transport and metabolism of metabolites of vitamin D, including the key calciotropic hormone 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3).

Methods

We have investigated intra-intronic variable tandem (TAAA)n-Alu repeat expansion in the DBP gene in 170 men, comprising healthy male subjects and men with idiopathic osteoporosis and low trauma fractures.

Results and conclusions

The predominant DBP-Alu genotype in the control subjects was 10/10 (frequency 0.421), whereas the frequency of this genotype in men with osteoporosis was 0.089. DBP-Alu alleles *10, *8 and *9, respectively, were the three commonest in both healthy subjects and men with osteoporosis. Allele *10 was associated with a lower risk of osteoporosis (OR 0.39, 95% CI 0.25-0.64; p < 0.0005), as was allele *11 (odds ratio 0.09, 95% CI 0.01-0.67; p < 0.007). Logistic regression gave similar results, showing that individuals with genotype 10/10 and 19-20 repeats (genotypes 9/10, 9/11, 10/10,) are protected from fracture or osteoporosis. Overall, there was a relationship between DBP Alu genotype and BMD, suggesting that DBP-Alu genotype may influence fracture risk. This effect may be mediated by changes in the circulating concentrations of DBP which influences free concentrations of vitamin D."xsd:string
http://purl.uniprot.org/citations/18038108http://purl.org/dc/terms/identifier"doi:10.1007/s00198-007-0516-8"xsd:string
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/author"Tuck S.P."xsd:string
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/author"Datta H.K."xsd:string
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/author"Francis R.M."xsd:string
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/author"Mastana S.S."xsd:string
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/author"Al-oanzi Z.H."xsd:string
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/author"Cook D.B."xsd:string
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/author"Summers G.D."xsd:string
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/name"Osteoporos Int"xsd:string
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/pages"951-960"xsd:string
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/title"Vitamin D-binding protein gene microsatellite polymorphism influences BMD and risk of fractures in men."xsd:string
http://purl.uniprot.org/citations/18038108http://purl.uniprot.org/core/volume"19"xsd:string
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