| http://purl.uniprot.org/citations/18039831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18039831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18039831 | http://www.w3.org/2000/01/rdf-schema#comment | "In some patients, Escherichia coli strains establish significant bacteriuria without causing symptoms of urinary tract infection (UTI). These asymptomatic-bacteriuria (ABU) strains have been shown to express fewer virulence factors than the uropathogenic E. coli (UPEC) strains that cause severe, symptomatic UTI. Paradoxically, ABU strains carry many typical UPEC virulence genes, and the molecular basis of their low virulence therefore remains unclear. This study examined whether ABU strains might evolve from UPEC by genome loss and virulence gene attenuation. The presence of conserved E. coli K-12 genes was examined using an E. coli K-12 strain MG1655-specific DNA array and the distribution of UPEC virulence-related genes was examined with the E. coli pathoarray. Two groups of strains could be distinguished. Several ABU strains were shown by multilocus sequence typing and by comparative genomic analyses to be related to UPEC but to have smaller genome sizes. There were significant alterations in essential virulence genes, including reductive evolution by point mutations, DNA rearrangements, and deletions. Other strains were unrelated to UPEC and lacked most of the virulence-associated genes. The results suggest that some ABU strains arise from virulent strains by attenuation of virulence genes while others are nonvirulent and resemble commensal strains. We propose that virulence attenuation might constitute a general mechanism for mucosal pathogens to evolve toward commensalism."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.org/dc/terms/identifier | "doi:10.1128/IAI.01215-07"xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.01215-07"xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/author | "Dobrindt U."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/author | "Dobrindt U."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/author | "Hacker J."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/author | "Hacker J."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/author | "Svanborg C."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/author | "Svanborg C."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/author | "Wullt B."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/author | "Wullt B."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/author | "Zdziarski J."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/author | "Zdziarski J."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/name | "Infect. Immun."xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/pages | "695-703"xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/pages | "695-703"xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/title | "Molecular basis of commensalism in the urinary tract: low virulence or virulence attenuation?"xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/title | "Molecular basis of commensalism in the urinary tract: low virulence or virulence attenuation?"xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/volume | "76"xsd:string |
| http://purl.uniprot.org/citations/18039831 | http://purl.uniprot.org/core/volume | "76"xsd:string |