| http://purl.uniprot.org/citations/18039879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18039879 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila dec-1 gene produces three proproteins required for female fertility and eggshell assembly. The three proproteins are distinguished by their C termini. Fc106, the most abundant proprotein, is cleaved within the vitelline membrane to three mature derivatives in a developmentally regulated manner. To define sequences within fc106 that are critical for its function, we created wild-type and mutant versions of an fc106 cDNA transgene. The functional consequences of the mutations were assessed in dec-14, a female-sterile splicing mutant that does not produce the fc106 isoform. The fertility of dec-14 females was restored by the introduction of either a wild-type transgene or a transgene bearing a C-terminal deletion that included fc106-specific sequences. Surprisingly, the removal of internal coding sequences created an aberrant DEC-1 proprotein that induced female sterility when introduced into wild-type flies. Dominant female sterility was not associated with larger deletions that included the fc106 N terminus, suggesting that abnormal juxtaposition of N- and C-terminal sequences in the aberrant proprotein interfered with endogenous DEC-1 proteins. Changes in the fractionation behavior of the endogenous fc106 C-terminal derivative, s60, and morphological changes in the endochorion in response to expression of the aberrant proprotein support this interpretation."xsd:string |
| http://purl.uniprot.org/citations/18039879 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.107.080168"xsd:string |
| http://purl.uniprot.org/citations/18039879 | http://purl.uniprot.org/core/author | "Waring G.L."xsd:string |
| http://purl.uniprot.org/citations/18039879 | http://purl.uniprot.org/core/author | "Spangenberg D.K."xsd:string |
| http://purl.uniprot.org/citations/18039879 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18039879 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/18039879 | http://purl.uniprot.org/core/pages | "1595-1608"xsd:string |
| http://purl.uniprot.org/citations/18039879 | http://purl.uniprot.org/core/title | "A mutant dec-1 transgene induces dominant female sterility in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/18039879 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/18039879 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18039879 |
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| http://purl.uniprot.org/uniprot/#_M9NEA7-mappedCitation-18039879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18039879 |
| http://purl.uniprot.org/uniprot/#_M9NEY9-mappedCitation-18039879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18039879 |
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| http://purl.uniprot.org/uniprot/#_P18171-mappedCitation-18039879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18039879 |
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| http://purl.uniprot.org/uniprot/P18169 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18039879 |
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| http://purl.uniprot.org/uniprot/M9NEA7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18039879 |