| http://purl.uniprot.org/citations/18039968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18039968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18039968 | http://www.w3.org/2000/01/rdf-schema#comment | "During vertebrate development, signaling by the TGFbeta ligand Nodal is critical for mesoderm formation, correct positioning of the anterior-posterior axis, normal anterior and midline patterning, and left-right asymmetric development of the heart and viscera. Stimulation of Alk4/EGF-CFC receptor complexes by Nodal activates Smad2/3, leading to left-sided expression of target genes that promote asymmetric placement of certain internal organs. We identified Ttrap as a novel Alk4- and Smad3-interacting protein that controls gastrulation movements and left-right axis determination in zebrafish. Morpholino-mediated Ttrap knockdown increases Smad3 activity, leading to ectopic expression of snail1a and apparent repression of e-cadherin, thereby perturbing cell movements during convergent extension, epiboly and node formation. Thus, although the role of Smad proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad partner that plays an essential role in the fine-tuning of this signal transduction cascade."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.000026"xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.000026"xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Waelkens E."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Waelkens E."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Collen D."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Collen D."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Nelles L."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Nelles L."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Derua R."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Derua R."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Carmeliet P."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Carmeliet P."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Crawford A.D."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Crawford A.D."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Esguerra C.V."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Esguerra C.V."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Huylebroeck D."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Huylebroeck D."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Ibrahimi A."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Ibrahimi A."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Janssens E."xsd:string |
| http://purl.uniprot.org/citations/18039968 | http://purl.uniprot.org/core/author | "Janssens E."xsd:string |