| http://purl.uniprot.org/citations/18045535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18045535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18045535 | http://www.w3.org/2000/01/rdf-schema#comment | "NF-kappaB is a DNA-binding protein complex that transduces a variety of activating signals from the cytoplasm to specific sets of target genes. To understand the preferential recruitment of NF-kappaB to specific gene regulatory sites, we used NF-kappaB p65 in a tandem affinity purification and mass spectrometry proteomic screen. We identified ribosomal protein S3 (RPS3), a KH domain protein, as a non-Rel subunit of p65 homodimer and p65-p50 heterodimer DNA-binding complexes that synergistically enhances DNA binding. RPS3 knockdown impaired NF-kappaB-mediated transcription of selected p65 target genes but not nuclear shuttling or global protein translation. Rather, lymphocyte-activating stimuli caused nuclear translocation of RPS3, parallel to p65, to form part of NF-kappaB bound to specific regulatory sites in chromatin. Thus, RPS3 is an essential but previously unknown subunit of NF-kappaB involved in the regulation of key genes in rapid cellular activation responses. Our observations provide insight into how NF-kappaB selectively controls gene expression."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.10.009"xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.10.009"xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Anderson D.E."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Anderson D.E."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Lenardo M.J."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Lenardo M.J."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Wan F."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Wan F."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Staudt L.M."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Staudt L.M."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Deutsch W.A."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Deutsch W.A."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Hegde V."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Hegde V."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Lam L.T."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Lam L.T."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Levens D."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Levens D."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Snow A."xsd:string |
| http://purl.uniprot.org/citations/18045535 | http://purl.uniprot.org/core/author | "Snow A."xsd:string |