| http://purl.uniprot.org/citations/18045866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18045866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18045866 | http://www.w3.org/2000/01/rdf-schema#comment | "Memo (mediator of ErbB2-driven cell motility) is a 297-amino-acid protein recently shown to co-precipitate with the C terminus of ErbB2 and be required for ErbB2-driven cell motility. Memo is not homologous to any known signaling proteins, and how it mediates ErbB2 signals is not known. To provide a molecular basis for understanding Memo function, we have determined and report here the 2.1A crystal structure of human Memo and show it be homologous to class III nonheme iron-dependent dioxygenases, a structural class that now includes a zinc-binding protein of unknown function. No metal binding or enzymatic activity can be detected for Memo, but Memo does bind directly to a specific ErbB2-derived phosphopeptide encompassing Tyr-1227 using its vestigial enzymatic active site. Memo thus represents a new class of phosphotyrosine-binding protein."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m703523200"xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m703523200"xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/author | "Qiu C."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/author | "Qiu C."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/author | "Badache A."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/author | "Badache A."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/author | "Leahy D.J."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/author | "Leahy D.J."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/author | "Hynes N.E."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/author | "Hynes N.E."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/author | "Lienhard S."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/author | "Lienhard S."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/pages | "2734-2740"xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/pages | "2734-2740"xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/title | "Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/title | "Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site."xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18045866 | http://purl.uniprot.org/core/volume | "283"xsd:string |