| http://purl.uniprot.org/citations/18049476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18049476 | http://www.w3.org/2000/01/rdf-schema#comment | "X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis proteins family that selectively binds and inhibits caspase-3, -7 and -9. As such, XIAP is an extremely potent suppressor of apoptosis and an attractive target for cancer treatment. Che-1 is an antiapoptotic agent involved in the control of gene transcription and cell proliferation. Recently, we showed that the checkpoint kinases ATM/ATR and checkpoint kinase 2 physically and functionally interact with Che-1 and promote its phosphorylation and accumulation in response to DNA damage. These Che-1 modifications induce transcription of p53, and Che-1 depletion strongly sensitizes tumor cells to anticancer drugs. Here we show that Che-1 activates XIAP expression in response to DNA damage. This effect is mediated by Che-1 phosphorylation and requires NF-kappaB. Notably, we found that XIAP expression is necessary for antiapoptotic activity of Che-1 and that in vivo downregulation of Che-1 by small interference RNA strongly enhanced the cytotoxicity of anticancer drugs."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4402284"xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/author | "Bruno T."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/author | "De Nicola F."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/author | "Di Padova M."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/author | "Fanciulli M."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/author | "Floridi A."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/author | "Iezzi S."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/author | "Passananti C."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/author | "Leonetti C."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/author | "Di Certo M.G."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/author | "Scarsella M."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/author | "Desantis A."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/pages | "515-520"xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/title | "Che-1 activates XIAP expression in response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/18049476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18049476 |
| http://purl.uniprot.org/citations/18049476 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18049476 |
| http://purl.uniprot.org/uniprot/Q9NY61#attribution-40B396E64305A641664E886765141408 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18049476 |
| http://purl.uniprot.org/uniprot/Q9NY61#attribution-484593CEC61719DDAB8F7FF0024D80BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18049476 |
| http://purl.uniprot.org/uniprot/P98170#attribution-484593CEC61719DDAB8F7FF0024D80BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18049476 |