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http://purl.uniprot.org/citations/18052703http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18052703http://www.w3.org/2000/01/rdf-schema#comment"

Background

The pathobiology of rheumatoid arthritis (RA) is similar to that of periodontitis in that proinflammatory cytokines and immunoglobulin G Fc receptor (FcgammaR) play an important role. Functional polymorphisms of interleukin (IL)-1 and FcgammaR were shown to be associated with susceptibility to both diseases. Therefore, we evaluated whether the IL-1 and FcgammaR gene polymorphisms represent a common risk factor for RA and periodontitis.

Methods

The study population consisted of Japanese adults with RA (RA group; N = 100), periodontitis only (P group; N = 100), and healthy individuals with no systemic or oral disease (H group; N = 100). Clinical periodontal condition was defined by measurements of probing depth, clinical attachment level, and bleeding on probing. Genomic DNA was isolated from peripheral blood and analyzed for determination of IL-1 genotypes (IL-1A+4845, IL-1B+3954, and IL-1RN+2028) and FcgammaR genotypes (FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB) by allele-specific polymerase chain reactions.

Results

Among 100 patients with RA, 86% showed periodontal tissue destruction. However, the RA group exhibited milder levels of periodontal tissue destruction than the P group (P <0.01). There was a significant difference in the distribution of IL-1B+3954 C/T genotypes between the RA and P groups and between the RA and H groups (P = 0.03 for both comparisons), with enrichment of the T allele in the RA group (P = 0.04; odds ratio, 2.9 for both comparisons). The combination of IL-1A+4845 T and IL-1+3954 T alleles yielded a strong association with RA and periodontitis (RA versus P group: P = 0.00001; RA versus H group: P = 0.00001).

Conclusions

These results failed to show that IL-1 and FcgammaR gene polymorphisms constitute a common risk factor for RA and periodontitis. However, it was suggested that the distributions of IL-1B+3954 genotypes and IL-1A+4845 and IL-1B+3954 haplotypes were unique to the patients with RA and periodontitis."xsd:string
http://purl.uniprot.org/citations/18052703http://purl.org/dc/terms/identifier"doi:10.1902/jop.2007.070136"xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/author"Kobayashi T."xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/author"Ito S."xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/author"Yamamoto K."xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/author"Sumida T."xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/author"Gejyo F."xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/author"Kuroda T."xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/author"Sugita N."xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/author"Yoshie H."xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/author"Narita I."xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/name"J Periodontol"xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/pages"2311-2318"xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/title"The interleukin-1 and Fcgamma receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis."xsd:string
http://purl.uniprot.org/citations/18052703http://purl.uniprot.org/core/volume"78"xsd:string
http://purl.uniprot.org/citations/18052703http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18052703
http://purl.uniprot.org/citations/18052703http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18052703
http://purl.uniprot.org/uniprot/#_A0A0S2Z3S7-mappedCitation-18052703http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18052703
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http://purl.uniprot.org/uniprot/#_A0A2H4Z8E2-mappedCitation-18052703http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18052703
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