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http://purl.uniprot.org/citations/18054488http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18054488http://www.w3.org/2000/01/rdf-schema#comment"A series of potent thiol-containing aryl sulfone TACE inhibitors were designed and synthesized. The SAR and MMP selectivity of the series were investigated. In particular, compound 8b showed excellent in vitro potency against the isolated enzyme and good selectivity over MMP-2, -7, -8, -9, and -13. The X-ray structure of 8b in complex with TACE was also obtained."xsd:string
http://purl.uniprot.org/citations/18054488http://purl.org/dc/terms/identifier"doi:10.1016/j.bmcl.2007.11.014"xsd:string
http://purl.uniprot.org/citations/18054488http://purl.uniprot.org/core/author"Wei Y."xsd:string
http://purl.uniprot.org/citations/18054488http://purl.uniprot.org/core/author"Wang T."xsd:string
http://purl.uniprot.org/citations/18054488http://purl.uniprot.org/core/author"Perola E."xsd:string
http://purl.uniprot.org/citations/18054488http://purl.uniprot.org/core/author"Bandarage U.K."xsd:string
http://purl.uniprot.org/citations/18054488http://purl.uniprot.org/core/author"Come J.H."xsd:string
http://purl.uniprot.org/citations/18054488http://purl.uniprot.org/core/author"Rao B.G."xsd:string
http://purl.uniprot.org/citations/18054488http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18054488http://purl.uniprot.org/core/name"Bioorg Med Chem Lett"xsd:string
http://purl.uniprot.org/citations/18054488http://purl.uniprot.org/core/pages"44-48"xsd:string
http://purl.uniprot.org/citations/18054488http://purl.uniprot.org/core/title"Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones."xsd:string
http://purl.uniprot.org/citations/18054488http://purl.uniprot.org/core/volume"18"xsd:string
http://purl.uniprot.org/citations/18054488http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18054488
http://purl.uniprot.org/citations/18054488http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18054488
http://purl.uniprot.org/uniprot/#_P78536-mappedCitation-18054488http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18054488
http://purl.uniprot.org/uniprot/P78536http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18054488