| http://purl.uniprot.org/citations/18055455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18055455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18055455 | http://www.w3.org/2000/01/rdf-schema#comment | "Severe acute respiratory syndrome (SARS) is an acute infectious disease with significant mortality. A typical clinical feature associated with SARS is pulmonary fibrosis and the associated lung failure. However, the underlying mechanism remains elusive. In this study, we demonstrate that SARS-associated coronavirus (SARS-CoV) nucleocapsid (N) protein potentiates transforming growth factor-beta (TGF-beta)-induced expression of plasminogen activator inhibitor-1 but attenuates Smad3/Smad4-mediated apoptosis of human peripheral lung epithelial HPL1 cells. The promoting effect of N protein on the transcriptional responses of TGF-beta is Smad3-specific. N protein associates with Smad3 and promotes Smad3-p300 complex formation while it interferes with the complex formation between Smad3 and Smad4. These findings provide evidence of a novel mechanism whereby N protein modulates TGF-beta signaling to block apoptosis of SARS-CoV-infected host cells and meanwhile promote tissue fibrosis. Our results reveal a novel mode of Smad3 action in a Smad4-independent manner and may lead to successful strategies for SARS treatment by targeting the TGF-beta signaling molecules."xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m708033200"xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m708033200"xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/author | "Nicholls J.M."xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/author | "Nicholls J.M."xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/author | "Chen Y.G."xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/author | "Chen Y.G."xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/pages | "3272-3280"xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/pages | "3272-3280"xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/title | "Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling."xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/title | "Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling."xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18055455 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18055455 |
| http://purl.uniprot.org/citations/18055455 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18055455 |
| http://purl.uniprot.org/citations/18055455 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18055455 |
| http://purl.uniprot.org/citations/18055455 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18055455 |