| http://purl.uniprot.org/citations/18055841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18055841 | http://www.w3.org/2000/01/rdf-schema#comment | "CD38 is involved in normal airway function, IL-13-induced airway hyperresponsiveness (AHR), and is also regulated by tumor necrosis factor (TNF)-alpha in airway smooth muscle (ASM) cells. This study aimed to determine whether TNF-alpha-induced CD38 upregulation in ASM cells contributes to AHR, a hallmark of asthma. We hypothesized that AHR would be attenuated in TNF-alpha-exposed CD38-deficient (CD38KO) mice compared with wild-type (WT) controls. Mice (n = 6-8/group) were intranasally challenged with vehicle control or TNF-alpha (50 ng) once and every other day during 1 or 4 wk. Lung inflammation and AHR, measured by changes in lung resistance after inhaled methacholine, were assessed 24 h following the last challenge. Tracheal rings were incubated with TNF-alpha (50 ng/ml) to assess contractile changes in the ASM. While a single TNF-alpha challenge caused no airway inflammation, both multiple-challenge protocols induced equally significant inflammation in CD38KO and WT mice. A single intranasal TNF-alpha challenge induced AHR in the WT but not in the CD38KO mice, whereas both mice developed AHR after 1 wk of challenges. The AHR was suppressed by extending the challenges for 4 wk in both mice, although to a larger magnitude in the WT than in the CD38KO mice. TNF-alpha increased ASM contractile properties in tracheal rings from WT but not from CD38KO mice. In conclusion, CD38 contributes to TNF-alpha-induced AHR after a brief airway exposure to the cytokine, likely by mediating changes in ASM contractile responses, and is associated with greater AHR remission following chronic airway exposure to TNF-alpha. The mechanisms involved in this remission remain to be determined."xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.00367.2007"xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://purl.uniprot.org/core/author | "Kita H."xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://purl.uniprot.org/core/author | "Lund F.E."xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://purl.uniprot.org/core/author | "Kannan M.S."xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://purl.uniprot.org/core/author | "Jude J.A."xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://purl.uniprot.org/core/author | "Guedes A.G."xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://purl.uniprot.org/core/author | "Paulin J."xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18055841 | http://purl.uniprot.org/core/name | "Am J Physiol Lung Cell Mol Physiol"xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://purl.uniprot.org/core/pages | "L290-9"xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://purl.uniprot.org/core/title | "Role of CD38 in TNF-alpha-induced airway hyperresponsiveness."xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://purl.uniprot.org/core/volume | "294"xsd:string |
| http://purl.uniprot.org/citations/18055841 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18055841 |
| http://purl.uniprot.org/citations/18055841 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18055841 |
| http://purl.uniprot.org/uniprot/#_P56528-mappedCitation-18055841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18055841 |
| http://purl.uniprot.org/uniprot/#_Q4FJL8-mappedCitation-18055841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18055841 |
| http://purl.uniprot.org/uniprot/#_Q3UCS6-mappedCitation-18055841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18055841 |
| http://purl.uniprot.org/uniprot/#_Q76N18-mappedCitation-18055841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18055841 |
| http://purl.uniprot.org/uniprot/Q3UCS6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18055841 |
| http://purl.uniprot.org/uniprot/P56528 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18055841 |
| http://purl.uniprot.org/uniprot/Q4FJL8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18055841 |
| http://purl.uniprot.org/uniprot/Q76N18 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18055841 |