| http://purl.uniprot.org/citations/18056040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18056040 | http://www.w3.org/2000/01/rdf-schema#comment | "Wear particles produced from artificial joint prostheses are known to cause macrophage-monocyte lineage cells to produce proosteoclastogenic cytokines, including tumor necrosis factor (TNF)-alpha. The specific molecular mechanism, however, is not yet known. Bioinformatic analysis showed that the promoter region of TNF-alpha has several consensus sequences for NFAT binding. Consequently, we examined the role of nuclear factor of activated T cells (NFAT) in TNF-alpha production. Our investigation has shown that treatment with titanium nanoparticles increased TNF-alpha gene expression along with TNF-alpha protein secretion in murine macrophage-like RAW264.7 and primary monocyte-macrophage cells. Titanium particle-induced TNF-alpha induction was inhibited by VIVIT, a peptide inhibitor that targets the calcineurin/NFAT axis, which suggests that NFAT mediates metallic particle-induced TNF-alpha expression in monocyte-macrophage lineage cells."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.org/dc/terms/identifier | "doi:10.1196/annals.1402.026"xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/author | "Kim D.W."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/author | "Lee F.Y."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/author | "Seo S.W."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/author | "Macian F."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/author | "Shin M.J."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/author | "Minematsu H."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/author | "Blaine T.A."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/author | "Celil Aydemir A.B."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/author | "Young-In Lee F."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/name | "Ann N Y Acad Sci"xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/pages | "143-150"xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/title | "Orthopedic implant particle-induced tumor necrosis factor-alpha production in macrophage-monocyte lineage cells is mediated by nuclear factor of activated T cells."xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://purl.uniprot.org/core/volume | "1117"xsd:string |
| http://purl.uniprot.org/citations/18056040 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18056040 |
| http://purl.uniprot.org/citations/18056040 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18056040 |
| http://purl.uniprot.org/uniprot/#_Q0X0E6-mappedCitation-18056040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056040 |
| http://purl.uniprot.org/uniprot/#_A2AQC8-mappedCitation-18056040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056040 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-18056040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056040 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-18056040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056040 |
| http://purl.uniprot.org/uniprot/#_B5B2P6-mappedCitation-18056040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056040 |