| http://purl.uniprot.org/citations/18056360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18056360 | http://www.w3.org/2000/01/rdf-schema#comment | "The transmembrane chemokine CXCL 16 (CXCL16), which is the same molecule as the scavenger receptor that binds phosphatidylserine and oxidized lipoprotein (SR-PSOX), has been shown to mediate chemotaxis and adhesion of CXC chemokine receptor 6-expressing cells such as NKT and activated Th1 cells. We generated SR-PSOX/CXCL16-deficient mice and examined the role of this chemokine in vivo. The mutant mice showed a reduced number of liver NKT cells, and decreased production of IFN-gamma and IL-4 by administration of alpha-galactosylceramide (alphaGalCer). Of note, the alphaGalCer-induced production of IFN-gamma was more severely impaired than the production of IL-4 in SR-PSOX-deficient mice. In this context, SR-PSOX-deficient mice showed impaired sensitivity to alphaGalCer-induced anti-tumor effect mediated by IFN-gamma from NKT cells. NKT cells from wild-type mice showed impaired production of IFN-gamma, but not IL-4, after their culture with alphaGalCer and APCs from mutant mice. Moreover, Propionibacterium acnes-induced in vivo Th1 responses were severely impaired in SR-PSOX-deficient as well as NKT KO mice. Taken together, SR-PSOX/CXCL16 plays an important role in not only the production of IFN-gamma by NKT cells, but also promotion of Th1-inclined immune responses mediated by NKT cells."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.179.12.8172"xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/author | "Taniguchi M."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/author | "Yonehara S."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/author | "Kita T."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/author | "Matsushima K."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/author | "Minami M."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/author | "Suematsu M."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/author | "Shimaoka T."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/author | "Kume N."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/author | "Seino K."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/author | "Nishime C."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/pages | "8172-8179"xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/title | "Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells."xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/18056360 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18056360 |
| http://purl.uniprot.org/citations/18056360 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18056360 |
| http://purl.uniprot.org/uniprot/#_A2CFE9-mappedCitation-18056360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056360 |
| http://purl.uniprot.org/uniprot/#_D9YM45-mappedCitation-18056360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056360 |
| http://purl.uniprot.org/uniprot/#_I7HIQ2-mappedCitation-18056360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056360 |
| http://purl.uniprot.org/uniprot/#_Q8BSU2-mappedCitation-18056360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056360 |
| http://purl.uniprot.org/uniprot/A2CFE9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18056360 |