| http://purl.uniprot.org/citations/18056429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18056429 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptosis is essential for proper development and tissue homeostasis in metazoans. It plays a critical role in generating sexual dimorphism by eliminating structures that are not needed in a specific sex. The molecular mechanisms that regulate sexually dimorphic apoptosis are poorly understood. Here we report the identification of the ceh-30 gene as a key regulator of sex-specific apoptosis in Caenorhabditis elegans. Loss-of-function mutations in ceh-30 cause the ectopic death of male-specific CEM neurons. ceh-30 encodes a BarH homeodomain protein that acts downstream from the terminal sex determination gene tra-1, but upstream of, or in parallel to, the cell-death-initiating gene egl-1 to protect CEM neurons from undergoing apoptosis in males. The second intron of the ceh-30 gene contains two adjacent cis-elements that are binding sites for TRA-1A and a POU-type homeodomain protein UNC-86 and acts as a sensor to regulate proper specification of the CEM cell fate. Surprisingly, the N terminus of CEH-30 but not its homeodomain is critical for CEH-30's cell death inhibitory activity in CEMs and contains a conserved eh1/FIL domain that is important for the recruitment of the general transcriptional repressor UNC-37/Groucho. Our study suggests that ceh-30 defines a critical checkpoint that integrates the sex determination signal TRA-1 and the cell fate determination and survival signal UNC-86 to control the sex-specific activation of the cell death program in CEMs through the general transcription repressor UNC-37."xsd:string |
| http://purl.uniprot.org/citations/18056429 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1607807"xsd:string |
| http://purl.uniprot.org/citations/18056429 | http://purl.uniprot.org/core/author | "Gengyo-Ando K."xsd:string |
| http://purl.uniprot.org/citations/18056429 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/18056429 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/18056429 | http://purl.uniprot.org/core/author | "Peden E."xsd:string |
| http://purl.uniprot.org/citations/18056429 | http://purl.uniprot.org/core/author | "Kimberly E."xsd:string |
| http://purl.uniprot.org/citations/18056429 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18056429 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/18056429 | http://purl.uniprot.org/core/pages | "3195-3207"xsd:string |
| http://purl.uniprot.org/citations/18056429 | http://purl.uniprot.org/core/title | "Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho."xsd:string |
| http://purl.uniprot.org/citations/18056429 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/18056429 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18056429 |
| http://purl.uniprot.org/citations/18056429 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18056429 |
| http://purl.uniprot.org/uniprot/P34708#attribution-72C96153215CA74A54FB180A7E00BBFE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18056429 |
| http://purl.uniprot.org/uniprot/P13528#attribution-72C96153215CA74A54FB180A7E00BBFE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18056429 |
| http://purl.uniprot.org/uniprot/#_P34708-mappedCitation-18056429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056429 |
| http://purl.uniprot.org/uniprot/#_O02482-mappedCitation-18056429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056429 |
| http://purl.uniprot.org/uniprot/#_Q22909-mappedCitation-18056429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056429 |
| http://purl.uniprot.org/uniprot/#_P13528-mappedCitation-18056429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18056429 |
| http://purl.uniprot.org/uniprot/P13528 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18056429 |
| http://purl.uniprot.org/uniprot/Q22909 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18056429 |
| http://purl.uniprot.org/uniprot/O02482 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18056429 |
| http://purl.uniprot.org/uniprot/P34708 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18056429 |