| http://purl.uniprot.org/citations/18057259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18057259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18057259 | http://www.w3.org/2000/01/rdf-schema#comment | "RIG-I senses intracellular virus-specific nucleic acid structures and initiates an antiviral response that induces interferon (IFN) production, which, in turn, activates the transcription of RIG-I to increase RIG-I protein levels. Upon intracellular poly(I:C) stimulation, however, the levels of RIG-I protein did not correlate with the expression patterns of RIG-I transcripts. When the ISG15 conjugation system was overexpressed, ISG15 was conjugated to RIG-I and cellular levels of the unconjugated form of RIG-I decreased. The ISGylation of RIG-I reduced levels of both basal and virus-induced IFN promoter activity. Levels of unconjugated RIG-I also decreased when 26S proteasome activity was blocked by treatment with MG132, ALLN, or Lactacystin. In the presence of MG132, ISG15 conjugation to RIG-I increased, and hence, the unconjugated form of RIG-I was reduced. In Ube1L(-/-) cells, which lack the ability to conjugate ISG15, basal levels of both RIG-I protein and transcripts were increased compared to those in wild-type cells. As a result, enhanced production of ISGs and enhanced IFN promoter activity in Ube1L(-/-) cells were observed, and the phenotype was restored to that of wild-type cells by the overexpression of Ube1L. Based on these results, we propose a novel negative feedback loop which adjusts the strength of the RIG-I-mediated antiviral response and IFN production through the regulation of RIG-I protein by IFN-induced ISG15 conjugation."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01650-07"xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01650-07"xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/author | "Kim M.J."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/author | "Kim M.J."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/author | "Imaizumi T."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/author | "Imaizumi T."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/author | "Hwang S.Y."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/author | "Hwang S.Y."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/author | "Yoo J.Y."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/author | "Yoo J.Y."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/pages | "1474-1483"xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/pages | "1474-1483"xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/title | "Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/title | "Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation."xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/volume | "82"xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://purl.uniprot.org/core/volume | "82"xsd:string |
| http://purl.uniprot.org/citations/18057259 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18057259 |
| http://purl.uniprot.org/citations/18057259 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18057259 |