| http://purl.uniprot.org/citations/18057374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18057374 | http://www.w3.org/2000/01/rdf-schema#comment | "We evaluated the impact of gender differences in both the quantitative and qualitative features of HDL subspecies on cellular free cholesterol efflux through the scavenger receptor class B type I (SR-BI), ABCA1, and ABCG1 pathways. For that purpose, healthy subjects (30 men and 26 women) matched for age, body mass index, triglyceride, apolipoprotein A-I, and high density lipoprotein-cholesterol (HDL-C) levels were recruited. We observed a significant increase (+14%; P < 0.03) in the capacity of whole sera from women to mediate cellular free cholesterol efflux via the SR-BI-dependent pathway compared with sera from men. Such enhanced efflux capacity resulted from a significant increase in plasma levels of large cholesteryl ester-rich HDL2 particles (+20%; P < 0.04) as well as from an enhanced capacity (+14%; P < 0.03) of these particles to mediate cellular free cholesterol efflux via SR-BI. By contrast, plasma from men displayed an enhanced free cholesterol efflux capacity (+31%; P < 0.001) via the ABCA1 transporter pathway compared with that from women, which resulted from a 2.4-fold increase in the plasma level of prebeta particles (P < 0.008). Moreover, in women, SR-BI-mediated cellular free cholesterol efflux was significantly correlated with plasma HDL-C (r = 0.72, P < 0.0001), whereas this relationship was not observed in men. In conclusion, HDL-C level may not represent the absolute indicator of the efficiency of the initial step of the reverse cholesterol transport."xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m700510-jlr200"xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/author | "Bruckert E."xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/author | "Guerin M."xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/author | "Catalano G."xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/author | "Chapman M.J."xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/author | "Le Goff W."xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/author | "Duchene E."xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/author | "Julia Z."xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/pages | "635-643"xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/title | "Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjects."xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/18057374 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18057374 |
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| http://purl.uniprot.org/uniprot/#_B4E3I1-mappedCitation-18057374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18057374 |
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| http://purl.uniprot.org/uniprot/#_B1AMI2-mappedCitation-18057374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18057374 |