| http://purl.uniprot.org/citations/18057719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18057719 | http://www.w3.org/2000/01/rdf-schema#comment | "In vitro metabolism of nobiletin, a polymethoxy-flavonoid abundantly present in citrus peels, was studied using liver microsomes of rats, hamsters and guinea pigs and ten cDNA-expressed rat cytochrome P450 (P450). The effects of P450 inducers on nobiletin metabolism were also investigated. Aerobical incubation with NADPH and animal liver microsomes transformed nobiletin to five metabolites, M-1, M-2, M-3, M-4 and M-5. From LC-MS and (1)H-NMR data and a time-course study, these were assumed to be 4'-hydroxy (OH)-, 7-OH-, 6-OH-, 3',4'-diOH- and 6,7-diOH-metabolites, respectively. Pretreatment of animals with phenobarbital increased M-2 and M-3 to about 2-fold that in untreated animals. Pretreatment with 3-methylcholanthrene (MC) resulted in remarkable increases of both M-1 and M-4 (3 to 9-fold that of untreated). Males had 2-3 times higher M-2 and M-3 formation activities in rats, and for M-2 in hamsters than did females. Immunoinhibition study using antiserum against P450 revealed the involvement of hamster CYP1A2 in the formation of M-1 and M-4 in hamster liver. Of ten rat P450s, CYP2C11, CYP3A1, CYP3A2 and CYP2D1 had high activities for the formation of M-1, M-2 and M-3. Another P450s (CYP1A1, CYP2C12 and CYP1A2) also showed activity for the formation of M-1. Only CYP1A1 produced 3',4'-diOH-metabolites (M-4). However, CYP2A1, CYP2B1 and CYP2E1 had no activity for nobiletin. These results suggested that constitutive P450s such as CYP2C11, CYP2D1, CYP3A1, CYP3A2 and CYP2C12 are responsible for the demethylation at the 6-, 7-, 3'- and 4'-positions; whereas, MC-inducible P450s, CYP1A1 and CYP1A2, preferentially catalyzed demethylation at the 3'-and 4'-positions."xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.org/dc/terms/identifier | "doi:10.1248/bpb.30.2317"xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/author | "Kato Y."xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/author | "Ohta H."xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/author | "Matsuo M."xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/author | "Yano M."xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/author | "Matsuoka M."xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/author | "Ishii T."xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/author | "Haraguchi K."xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/author | "Ohta C."xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/author | "Koga N."xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/name | "Biol Pharm Bull"xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/pages | "2317-2323"xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/title | "Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450."xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/18057719 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18057719 |
| http://purl.uniprot.org/citations/18057719 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18057719 |
| http://purl.uniprot.org/uniprot/P04800#attribution-40BB965AFDE62802C13DAE9E305B7EF1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18057719 |
| http://purl.uniprot.org/uniprot/P00185#attribution-40BB965AFDE62802C13DAE9E305B7EF1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18057719 |
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| http://purl.uniprot.org/uniprot/#_A0A8I6A1G5-mappedCitation-18057719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18057719 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JT98-mappedCitation-18057719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18057719 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AIP2-mappedCitation-18057719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18057719 |