| http://purl.uniprot.org/citations/18060044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18060044 | http://www.w3.org/2000/01/rdf-schema#comment | "Parasympathetic stimulation of the heart, which provides protection from arrhythmias and sudden death, involves activation of the G protein-coupled inward rectifying K+ channel GIRK1/4 and results in an acetylcholine-sensitive K+ current, I KACh. We describe a unique relationship between lipid homeostasis, the lipid-sensitive transcription factor SREBP-1, regulation of the cardiac parasympathetic response, and the development of ventricular arrhythmia. In embryonic chick atrial myocytes, lipid lowering by culture in lipoprotein-depleted serum increased SREBP-1 levels, GIRK1 expression, and I KACh activation. Regulation of the GIRK1 promoter by SREBP-1 and lipid lowering was dependent on interaction with 2 tandem sterol response elements and an upstream E-box motif. Expression of dominant negative SREBP-1 (DN-SREBP-1) reversed the effect of lipid lowering on I KACh and GIRK1. In SREBP-1 knockout mice, both the response of the heart to parasympathetic stimulation and the expression of GIRK1 were reduced compared with WT. I KACh, attenuated in atrial myocytes from SREBP-1 knockout mice, was stimulated by SREBP-1 expression. Following myocardial infarction, SREBP-1 knockout mice were twice as likely as WT mice to develop ventricular tachycardia in response to programmed ventricular stimulation. These results demonstrate a relationship between lipid metabolism and parasympathetic response that may play a role in arrhythmogenesis."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci32011"xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Liao R."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Shimano H."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Galper J.B."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Blaustein R.O."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Begley U."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Du C."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Georgescu S.P."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Karas R.H."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Park H.J."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Osborne T.F."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Van Tol H.H."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Aronovitz M.J."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Patten R.D."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Link M.S."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Welzig C.M."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/author | "Madias C."xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/pages | "259-271"xsd:string |
| http://purl.uniprot.org/citations/18060044 | http://purl.uniprot.org/core/title | "Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP."xsd:string |