| http://purl.uniprot.org/citations/18061495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18061495 | http://www.w3.org/2000/01/rdf-schema#comment | "The aims of this study were to explore the relationship between clinical outcome and HER-2 protein expression in dogs with malignant mammary tumours after surgery and to determine the sequence of the HER-2 gene. Tissues from 91 dogs diagnosed with malignant mammary tumours, six with benign lesions and two normal mammary glands were analysed for the expression of HER-2 by immunohistochemistry (IHC). Exons 14-18 of the HER-2 gene were amplified by reverse transcriptase polymerase chain reaction and sequenced in 19 tumours with IHC scores >2+; larger coding regions of HER-2 were analysed in five tumours. HER-2 protein overexpression was found in 27/91 (29.7%) of canine malignant mammary tumours. Dogs with HER-2-overexpressing malignant mammary tumours tended to have a higher survival rate than those that expressed a normal level of HER-2 within 2 years of surgery. In 3/19 cases, HER-2 sequences had a single nucleotide polymorphism, T(1725)C, with no change in the amino acid identity (Cys). No other sequence aberration of HER-2 was found."xsd:string |
| http://purl.uniprot.org/citations/18061495 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.tvjl.2007.10.013"xsd:string |
| http://purl.uniprot.org/citations/18061495 | http://purl.uniprot.org/core/author | "Chang S.C."xsd:string |
| http://purl.uniprot.org/citations/18061495 | http://purl.uniprot.org/core/author | "Wong M.L."xsd:string |
| http://purl.uniprot.org/citations/18061495 | http://purl.uniprot.org/core/author | "Hsu W.L."xsd:string |
| http://purl.uniprot.org/citations/18061495 | http://purl.uniprot.org/core/author | "Huang H.M."xsd:string |
| http://purl.uniprot.org/citations/18061495 | http://purl.uniprot.org/core/author | "Liao J.W."xsd:string |
| http://purl.uniprot.org/citations/18061495 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18061495 | http://purl.uniprot.org/core/name | "Vet J"xsd:string |
| http://purl.uniprot.org/citations/18061495 | http://purl.uniprot.org/core/pages | "116-123"xsd:string |
| http://purl.uniprot.org/citations/18061495 | http://purl.uniprot.org/core/title | "Increased survival in dogs with malignant mammary tumours overexpressing HER-2 protein and detection of a silent single nucleotide polymorphism in the canine HER-2 gene."xsd:string |
| http://purl.uniprot.org/citations/18061495 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18061495 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18061495 |
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