| http://purl.uniprot.org/citations/18064602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18064602 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factor-21 (FGF-21) is a metabolic regulator that can influence glucose and lipid control in diabetic rodents and primates. We demonstrate that betaKlotho is an integral part of an activated FGF-21-betaKlotho-FGF receptor (FGFR) complex thus a critical subunit of the FGF-21 receptor. Cells lacking betaKlotho did not respond to FGF-21; the introduction of betaKlotho to these cells conferred FGF-21-responsiveness and recapitulated the entire scope of FGF-21 signaling observed in naturally responsive cells. Interestingly, FGF-21-mediated effects are heparin independent suggesting that betaKlotho plays a role in FGF-21 activity similar to the one played by heparin in the signaling of conventional FGFs. Moreover, in addition to conferring specificity for FGF-21, betaKlotho appears to support FGF-19 activity and mediates the receptor selectivity profile of FGF-19. All together, these results indicate that betaKlotho and FGFRs form the cognate FGF-21 receptor complex, mediating FGF-21 cellular specificity and physiological effects."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.21357"xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Ding L."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Coskun T."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Hale J.E."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Knierman M.D."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Bright S."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Bina H.A."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Dunbar J.D."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Kharitonenkov A."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Micanovic R."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Moyers J.S."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Shanafelt A.B."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/author | "Mehrbod S.F."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/pages | "1-7"xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/title | "FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho."xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://purl.uniprot.org/core/volume | "215"xsd:string |
| http://purl.uniprot.org/citations/18064602 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18064602 |
| http://purl.uniprot.org/citations/18064602 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18064602 |
| http://purl.uniprot.org/uniprot/#_A0A7U3L6A3-mappedCitation-18064602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18064602 |
| http://purl.uniprot.org/uniprot/#_Q9JJN1-mappedCitation-18064602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18064602 |