| http://purl.uniprot.org/citations/18064672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18064672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18064672 | http://www.w3.org/2000/01/rdf-schema#comment | "Attractin (ATRN) and Attractin-like 1 (ATRNL1) are highly similar type I transmembrane proteins. Atrn null mutant mice have a pleiotropic phenotype including dark fur, juvenile-onset spongiform neurodegeneration, hypomyelination, tremor, and reduced body weight and adiposity, implicating ATRN in numerous biological processes. Bioinformatic analysis indicated that Atrn and Atrnl1 arose from a common ancestral gene early in vertebrate evolution. To investigate the genetics of the ATRN system and explore potential redundancy between Atrn and Atrnl1, we generated and characterized Atrnl1 loss- and gain-of-function mutations in mice. Atrnl1 mutant mice were grossly normal with no alterations of pigmentation, central nervous system pathology or body weight. Atrn null mutant mice carrying a beta-actin promoter-driven Atrnl1 transgene had normal, agouti-banded hairs and significantly delayed onset of spongiform neurodegeneration, indicating that over-expression of ATRNL1 compensates for loss of ATRN. Thus, the two genes are redundant from the perspective of gain-of-function but not loss-of-function mutations."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvg.20351"xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvg.20351"xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Shen S."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Shen S."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Aradhya S."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Aradhya S."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Barsh G.S."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Barsh G.S."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Azarani A."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Azarani A."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Gunn T.M."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Gunn T.M."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Hu C.-L."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Hu C.-L."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Walker W.P."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/author | "Walker W.P."xsd:string |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18064672 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |