| http://purl.uniprot.org/citations/18066067 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18066067 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18066067 | http://www.w3.org/2000/01/rdf-schema#comment | "During a genome-wide screen with RNA-mediated interference, we isolated CG8580 as a gene involved in the innate immune response of Drosophila melanogaster. CG8580, which we called Akirin, encoded a protein that acted in parallel with the NF-kappaB transcription factor downstream of the Imd pathway and was required for defense against Gram-negative bacteria. Akirin is highly conserved, and the human genome contains two homologs, one of which was able to rescue the loss-of-function phenotype in drosophila cells. Akirins were strictly localized to the nucleus. Knockout of both Akirin homologs in mice showed that one had an essential function downstream of the Toll-like receptor, tumor necrosis factor and interleukin (IL)-1beta signaling pathways leading to the production of IL-6. Thus, Akirin is a conserved nuclear factor required for innate immune responses."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1543"xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1543"xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Boutros M."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Boutros M."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Matsushita K."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Matsushita K."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Goto A."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Goto A."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "El Chamy L."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "El Chamy L."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Gesellchen V."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Gesellchen V."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Hoffmann J.A."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Hoffmann J.A."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Kuttenkeuler D."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Kuttenkeuler D."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Reichhart J.-M."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Reichhart J.-M."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/18066067 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |