| http://purl.uniprot.org/citations/18067272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18067272 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor alpha (TNFalpha) triggers a signaling pathway converging on the activation of NF-kappaB, which forms the basis for many physiological and pathological processes. In a kinase gene screen using a NF-kappaB reporter, we observed that overexpression of casein kinase 1alpha (CK1alpha) enhanced TNFalpha-induced NF-kappaB activation, and a CK1alpha kinase dead mutant, CK1alpha (K46A), reduced NF-kappaB activation induced by TNFalpha. We subsequently demonstrated that CK1alpha interacted with receptor interacting protein 1 (RIP1) but not with TRADD, TRAF2, MEKK3, IKKalpha, IKKbeta, or IKKgamma in mammalian cells. RIP1 is an indispensable molecule in TNFalpha/NF-kappaB signaling. We demonstrated that CK1alpha interacted with and phosphorylated RIP1 at the intermediate domain. Finally, we showed that CK1alpha enhanced RIP1-mediated NF-kappaB activation. Taken together, our studies suggest that CK1alpha is another kinase that regulates RIP1 function in NF-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi7010515"xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Luo Y."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Gu C."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Peng X."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Qiang B."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Tan F."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/author | "Xu B.E."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/pages | "441-448"xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/title | "Casein kinase 1alpha interacts with RIP1 and regulates NF-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/18067272 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18067272 |
| http://purl.uniprot.org/citations/18067272 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18067272 |
| http://purl.uniprot.org/uniprot/#_A0A5F9W493-mappedCitation-18067272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18067272 |
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| http://purl.uniprot.org/uniprot/#_B3KU53-mappedCitation-18067272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18067272 |