| http://purl.uniprot.org/citations/18069897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18069897 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein Phosphatase type 2A (PP2A) represents a family of holoenzyme complexes with diverse biological activities. Specific holoenzyme complexes are thought to be deregulated during oncogenic transformation and oncogene-induced signaling. Since most studies on the role of this phosphatase family have relied on the use of generic PP2A inhibitors, the contribution of individual PP2A holoenzyme complexes in PP2A-controlled signaling pathways is largely unclear. To gain insight into this, we have constructed a set of shRNA vectors targeting the individual PP2A regulatory subunits for suppression by RNA interference. Here, we identify PR55gamma and PR55delta as inhibitors of c-Jun NH(2)-terminal kinase (JNK) activation by UV irradiation. We show that PR55gamma binds c-SRC and modulates the phosphorylation of serine 12 of c-SRC, a residue we demonstrate to be required for JNK activation by c-SRC. We also find that the physical interaction between PR55gamma and c-SRC is sensitive to UV irradiation. Our data reveal a novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma."xsd:string |
| http://purl.uniprot.org/citations/18069897 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.0030218"xsd:string |
| http://purl.uniprot.org/citations/18069897 | http://purl.uniprot.org/core/author | "Bernards R."xsd:string |
| http://purl.uniprot.org/citations/18069897 | http://purl.uniprot.org/core/author | "van Dam H."xsd:string |
| http://purl.uniprot.org/citations/18069897 | http://purl.uniprot.org/core/author | "Wilhelmsen K."xsd:string |
| http://purl.uniprot.org/citations/18069897 | http://purl.uniprot.org/core/author | "Creyghton M.P."xsd:string |
| http://purl.uniprot.org/citations/18069897 | http://purl.uniprot.org/core/author | "Eichhorn P.J."xsd:string |
| http://purl.uniprot.org/citations/18069897 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18069897 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/18069897 | http://purl.uniprot.org/core/pages | "e218"xsd:string |
| http://purl.uniprot.org/citations/18069897 | http://purl.uniprot.org/core/title | "A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC."xsd:string |
| http://purl.uniprot.org/citations/18069897 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/18069897 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18069897 |
| http://purl.uniprot.org/citations/18069897 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18069897 |
| http://purl.uniprot.org/uniprot/#_Q14925-mappedCitation-18069897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18069897 |
| http://purl.uniprot.org/uniprot/#_P45983-mappedCitation-18069897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18069897 |
| http://purl.uniprot.org/uniprot/#_L8ECI7-mappedCitation-18069897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18069897 |
| http://purl.uniprot.org/uniprot/#_P12931-mappedCitation-18069897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18069897 |
| http://purl.uniprot.org/uniprot/#_Q71UK5-mappedCitation-18069897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18069897 |
| http://purl.uniprot.org/uniprot/#_Q59GC6-mappedCitation-18069897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18069897 |
| http://purl.uniprot.org/uniprot/#_Q9H7V3-mappedCitation-18069897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18069897 |
| http://purl.uniprot.org/uniprot/#_Q9Y2T4-mappedCitation-18069897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18069897 |
| http://purl.uniprot.org/uniprot/P12931 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18069897 |
| http://purl.uniprot.org/uniprot/Q59GC6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18069897 |