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http://purl.uniprot.org/citations/18070145http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18070145http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Apart from the constitutively activating mutation of the G-protein alpha subunit (Gsalpha) (gsp mutation), factors involved in tumorigenesis or those in tumour behaviour remain elusive in sporadic GH-secreting pituitary adenomas. Recently, the N-terminally truncated form of fibroblast growth factor receptor-4 (ptd-FGFR4) was identified in pituitary adenomas. This aberrant receptor has transforming activity, and causes pituitary adenomas in transgenic mice. The clinical relevance of this receptor warrants investigation. Our objective was twofold: first, to examine how the expression of ptd-FGFR4 relates to gsp mutations; and second, to see whether patients with this receptor have unique clinical characteristics.

Materials and methods

mRNA was extracted from excised adenomas of 45 Japanese acromegalic patients. ptd-FGFR4 expression and gsp mutations were determined by reverse transcription polymerase chain reaction (RT-PCR) and direct sequencing. Preoperative clinical data were collected by reviewing medical charts and pituitary magnetic resonance imaging (MRI) scans.

Results

ptd-FGFR4 mRNA expression was detected in 19 out of 45 tumours (42.2%) while gsp mutations were detected in 25 out of 45 tumours (55.6%). The prevalence of ptd-FGFR4 expression did not differ between gsp-positive (44.0%) and gsp-negative (40.0%) tumours (P = 1.00). ptd-FGFR4-positive tumours invaded the cavernous sinus more frequently (P = 0.0098) than did the ptd-FGFR4-negative tumours. Tumour size was not statistically different between ptd-FGFR4-positive and -negative tumours (P = 0.198). The presence of ptd-FGFR4 did not correlate with age at operation, sex, preoperative serum GH or IGF-1 levels.

Conclusions

We found that ptd-FGFR4 expression and gsp mutations occur independently of each other, and that ptd-FGFR4 expression is associated with more invasive tumours in patients with GH-secreting pituitary adenomas."xsd:string
http://purl.uniprot.org/citations/18070145http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-2265.2007.03062.x"xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/author"Fujita T."xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/author"Yamada S."xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/author"Takano K."xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/author"Sano T."xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/author"Morita K."xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/author"Teramoto A."xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/author"Takei M."xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/author"Osamura R.Y."xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/author"Yasufuku-Takano J."xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/name"Clin Endocrinol (Oxf)"xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/pages"435-441"xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/title"Expression of pituitary tumour-derived, N-terminally truncated isoform of fibroblast growth factor receptor 4 (ptd-FGFR4) correlates with tumour invasiveness but not with G-protein alpha subunit (gsp) mutation in human GH-secreting pituitary adenomas."xsd:string
http://purl.uniprot.org/citations/18070145http://purl.uniprot.org/core/volume"68"xsd:string
http://purl.uniprot.org/citations/18070145http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18070145
http://purl.uniprot.org/citations/18070145http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18070145
http://purl.uniprot.org/uniprot/#_P63092-mappedCitation-18070145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18070145
http://purl.uniprot.org/uniprot/#_A0A0S2Z3S5-mappedCitation-18070145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18070145
http://purl.uniprot.org/uniprot/#_A0A590UJF0-mappedCitation-18070145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18070145
http://purl.uniprot.org/uniprot/#_A0A0S2Z3H8-mappedCitation-18070145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18070145
http://purl.uniprot.org/uniprot/#_A0A7I2V5R6-mappedCitation-18070145http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18070145
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