| http://purl.uniprot.org/citations/18075502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18075502 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptosis and inflammation, important contributors to the progression of chronic kidney disease, can be influenced by clusterin (a secreted glycoprotein that regulates apoptosis) and nuclear factor-kappaB (NF-kappaB, a transcription factor modifying the expression of inflammatory genes). We studied proteinuria-induced renal disease and its influence on clusterin-mediated apoptosis. Exposure of cultured mouse proximal tubule epithelial cells to bovine serum albumin (BSA) resulted in activation of NF-kappaB and activator protein-1 (AP-1) within hours followed by a decline in their activation, decreased activation of extracellular signal-regulated kinases (ERK1/2), decreased cell-associated antiapoptotic Bcl-xL protein but increased apoptosis. Clusterin progressively increased in the media over a 3 day period. Clusterin siRNA blocked protein production, increased NF-kappaB activation, and significantly increased cellular Bcl-xL protein, thereby reducing spontaneous and BSA-induced apoptosis. An siRNA to the NF-kappaB inhibitor IkappaBalpha had similar results. BSA-stimulated NF-kappaB activation reciprocally decreased AP-1 activity by preventing ERK1/2 phosphorylation. These in vitro studies suggest that clusterin inhibits NF-kappaB-mediated antiapoptotic effects by the apparent stabilization of IkappaBalpha switching from promoting inflammation to apoptosis during proteinuria."xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.ki.5002563"xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/author | "Hayashi M."xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/author | "Jacob A."xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/author | "Quigg R.J."xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/author | "Puri T.S."xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/author | "Cunningham P.N."xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/author | "Takase O."xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/author | "Minto A.W."xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/name | "Kidney Int"xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/pages | "567-577"xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/title | "Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18075502 | http://purl.uniprot.org/core/volume | "73"xsd:string |
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