| http://purl.uniprot.org/citations/18076571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18076571 | http://www.w3.org/2000/01/rdf-schema#comment | "Adenomatous polyposis coli (APC), whose mutation causes colorectal cancers, is a key player in the Wnt signaling pathway. While the role of APC in inhibition of beta-catenin/LEF1-dependent activation of transformation-inducing genes has been intensively studied and well established, regulation of APC expression at the protein level is only partially understood. Here we report that APC is up-regulated by EDD, the mammalian orthologue of Drosophila melanogaster"hyperplastic discs" gene (hyd) that is considered to be a putative tumor suppressor. Screening of APC immunocomplexes by mass spectrometry identified EDD as a putative APC-interacting protein. Exogenously expressed and endogenous APC interacted with EDD in vivo. Indirect immunofluorescent analyses demonstrated that APC and EDD co-localized in the cytoplasm of the cell. Over-expression of EDD enhanced the protein expression level of APC and its binding partner Axin, resulting in inhibition of Wnt signaling downstream of beta-catenin. Conversely, siRNA knock-down of EDD down-regulated APC at the protein level without altering its mRNA level, causing enhanced protein expression of beta-catenin. Thus, through protein-protein interaction, EDD stabilizes APC and up-regulates APC's function to inhibit beta-catenin, suggesting that EDD could act as a colorectal tumor suppressor."xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2007.01138.x"xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/author | "Ohta T."xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/author | "Wu W."xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/author | "Koike A."xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/author | "Watts C.K."xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/author | "Henderson M."xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/author | "Iwatani T."xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/author | "Otsubo T."xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/author | "Ohshima R."xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/pages | "1339-1345"xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/title | "Putative tumor suppressor EDD interacts with and up-regulates APC."xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/18076571 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18076571 |
| http://purl.uniprot.org/citations/18076571 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18076571 |
| http://purl.uniprot.org/uniprot/P25054#attribution-8C89BF4A78C25B4917233B7822118A29 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18076571 |
| http://purl.uniprot.org/uniprot/Q61315#attribution-12F767D2797BB7B24A0DF7888E410F83 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18076571 |
| http://purl.uniprot.org/uniprot/O35625#attribution-8C89BF4A78C25B4917233B7822118A29 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18076571 |
| http://purl.uniprot.org/uniprot/Q80TP3#attribution-12F767D2797BB7B24A0DF7888E410F83 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18076571 |
| http://purl.uniprot.org/uniprot/O95071#attribution-8C89BF4A78C25B4917233B7822118A29 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18076571 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPG8-mappedCitation-18076571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18076571 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQC1-mappedCitation-18076571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18076571 |