| http://purl.uniprot.org/citations/18077588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18077588 | http://www.w3.org/2000/01/rdf-schema#comment | "Canonical Wnt/beta-catenin signaling has central roles in development and diseases, and is initiated by the action of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. We demonstrated previously that Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3) initiates Wnt/beta-catenin signaling. Here we show that both Fz and Dvl functions are critical for Wnt-induced Lrp6 phosphorylation through Fz-Lrp6 interaction. We also show that axin, a key scaffolding protein in the Wnt pathway, is required for Lrp6 phosphorylation via its ability to recruit Gsk3, and inhibition of Gsk3 at the plasma membrane blocks Wnt/beta-catenin signaling. Our results suggest a model that upon Wnt-induced Fz-Lrp6 complex formation, Fz recruitment of Dvl in turn recruits the axin-Gsk3 complex, thereby promoting Lrp6 phosphorylation to initiate beta-catenin signaling. We discuss the dual roles of the axin-Gsk3 complex and signal amplification by Lrp6-axin interaction during Wnt/beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.013540"xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Zeng X."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Wynshaw-Boris A."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Tamai K."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Woodgett J."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Hsieh J.C."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Harada Y."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Doble B."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Yokota C."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/author | "Almeida K."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/pages | "367-375"xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/title | "Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions."xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/18077588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18077588 |
| http://purl.uniprot.org/citations/18077588 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18077588 |
| http://purl.uniprot.org/uniprot/#_P56704-mappedCitation-18077588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18077588 |
| http://purl.uniprot.org/uniprot/#_B3KQA9-mappedCitation-18077588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18077588 |