| http://purl.uniprot.org/citations/18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18079119 | http://www.w3.org/2000/01/rdf-schema#comment | "(-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to be a potent chemopreventive agent. Recently, 67-kDa laminin receptor (67LR) has been identified as a cell surface receptor for EGCG that mediates the anticancer activity of EGCG. Indeed, expression of 67LR confers EGCG responsiveness to tumor cells; however, the molecular basis for the anticancer activity of EGCG in vivo is not entirely understood. Here we show that (i) using a direct genetic screen, eukaryotic translation elongation factor 1A (eEF1A) is identified as a component responsible for the anticancer activity of EGCG; (ii) through both eEF1A and 67LR, EGCG induces the dephosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) at Thr-696 and activates myosin phosphatase; and (iii) silencing of 67LR, eEF1A, or MYPT1 in tumor cells results in abrogation of EGCG-induced tumor growth inhibition in vivo. Additionally, we found that eEF1A is up-regulated by EGCG through 67LR. Overall, these findings implicate both eEF1A and MYPT1 in EGCG signaling for cancer prevention through 67LR."xsd:string |
| http://purl.uniprot.org/citations/18079119 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m707892200"xsd:string |
| http://purl.uniprot.org/citations/18079119 | http://purl.uniprot.org/core/author | "Yamada K."xsd:string |
| http://purl.uniprot.org/citations/18079119 | http://purl.uniprot.org/core/author | "Tachibana H."xsd:string |
| http://purl.uniprot.org/citations/18079119 | http://purl.uniprot.org/core/author | "Yano S."xsd:string |
| http://purl.uniprot.org/citations/18079119 | http://purl.uniprot.org/core/author | "Umeda D."xsd:string |
| http://purl.uniprot.org/citations/18079119 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18079119 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18079119 | http://purl.uniprot.org/core/pages | "3050-3058"xsd:string |
| http://purl.uniprot.org/citations/18079119 | http://purl.uniprot.org/core/title | "Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor."xsd:string |
| http://purl.uniprot.org/citations/18079119 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18079119 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18079119 |
| http://purl.uniprot.org/citations/18079119 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18079119 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG17-mappedCitation-18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079119 |
| http://purl.uniprot.org/uniprot/#_B2CY77-mappedCitation-18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079119 |
| http://purl.uniprot.org/uniprot/#_B2RAH5-mappedCitation-18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079119 |
| http://purl.uniprot.org/uniprot/#_P10126-mappedCitation-18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079119 |
| http://purl.uniprot.org/uniprot/#_Q4FZE5-mappedCitation-18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079119 |
| http://purl.uniprot.org/uniprot/#_Q3UZQ3-mappedCitation-18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079119 |
| http://purl.uniprot.org/uniprot/#_Q58E64-mappedCitation-18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079119 |
| http://purl.uniprot.org/uniprot/#_O14974-mappedCitation-18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079119 |
| http://purl.uniprot.org/uniprot/#_P08865-mappedCitation-18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079119 |
| http://purl.uniprot.org/uniprot/#_P14206-mappedCitation-18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079119 |
| http://purl.uniprot.org/uniprot/#_Q3TII3-mappedCitation-18079119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079119 |