| http://purl.uniprot.org/citations/18079403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18079403 | http://www.w3.org/2000/01/rdf-schema#comment | "RNA polymerase II (Pol II) transcribes genes that encode proteins and noncoding small nuclear RNAs (snRNAs). The carboxyl-terminal repeat domain (CTD) of the largest subunit of mammalian RNA Pol II, comprising tandem repeats of the heptapeptide consensus Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7, is required for expression of both gene types. We show that mutation of serine-7 to alanine causes a specific defect in snRNA gene expression. We also present evidence that phosphorylation of serine-7 facilitates interaction with the snRNA gene-specific Integrator complex. These findings assign a biological function to this amino acid and highlight a gene type-specific requirement for a residue within the CTD heptapeptide, supporting the existence of a CTD code."xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1145989"xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/author | "Taylor A."xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/author | "Murphy S."xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/author | "O'Reilly D."xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/author | "Eick D."xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/author | "Chapman R.D."xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/author | "Egloff S."xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/author | "Pitts L."xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/author | "Tanzhaus K."xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/pages | "1777-1779"xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/title | "Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression."xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://purl.uniprot.org/core/volume | "318"xsd:string |
| http://purl.uniprot.org/citations/18079403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18079403 |
| http://purl.uniprot.org/citations/18079403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18079403 |
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| http://purl.uniprot.org/uniprot/#_P52655-mappedCitation-18079403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079403 |
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| http://purl.uniprot.org/uniprot/#_P52747-mappedCitation-18079403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079403 |
| http://purl.uniprot.org/uniprot/#_Q15542-mappedCitation-18079403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079403 |
| http://purl.uniprot.org/uniprot/#_Q15543-mappedCitation-18079403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079403 |
| http://purl.uniprot.org/uniprot/#_Q15544-mappedCitation-18079403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18079403 |