| http://purl.uniprot.org/citations/18081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18081878 | http://www.w3.org/2000/01/rdf-schema#comment | "Glutathione S-transferase P (GST-P), a marker for rat hepatic preneoplastic lesions, is suggested to bind to Jun N-terminal kinase (JNK) to repress stress response, and GST-P gene expression is regulated by a transcription factor, nuclear factor-erythroid 2-related factor 2 (Nrf2). In this study, we examined by immunohistochemistry whether JNK2, p38 mitogen-activated protein kinase, and Nrf2 were expressed in GST-P-positive foci induced by the Solt-Farber protocol. At 2 weeks after partial hepatectomy, all GST-P-positive foci were negative for p38, and 86.4 +/- 5.6% and 64.7 +/-6.3% of GST-P-positive foci were negative for JNK2 and Nrf2, respectively. Western blot analysis showed decreased p38 mitogen-activated protein kinase and JNK2 expression in livers treated with the protocol. In immunohistochemistry, besides GST-P-positive foci, GST-P-negative foci were detected as p38-negative foci in the surrounding tissues positive for p38. In contrast to GST-P-positive foci, most GST-P-negative foci showed enhanced Nrf2 expression. The number of GST-P-negative foci was 76 +/-18/10 mm(2) of liver section at 2 weeks, but was undetectable at 1 week. The area of GST-P-negative foci was 0.09 +/-0.05 mm(2), smaller than that of GST-P-positive ones (0.29 +/-0.23). After treatment with carbon tetrachloride, small vacuoles due to liver injury were frequently observed inside GST-P-negative foci but less frequently in GST-P-positive foci. However, this treatment resulted in expression of JNK2, p38, and Nrf2 in both foci. These results showed development of GST-P-negative foci during the early stage of hepatocarcinogenesis and suggested that Nrf2 is not responsible for GST-P expression in rat hepatic preneoplastic foci."xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1349-7006.2007.00703.x"xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/author | "Fan Y."xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/author | "Shimizu T."xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/author | "Yamada T."xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/author | "Akita M."xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/author | "Tsuchida S."xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/author | "Asano J."xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/author | "Nanashima N."xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/pages | "497-501"xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/title | "Development of glutathione S-transferase-P-negative foci accompanying nuclear factor-erythroid 2-related factor 2 expression during early stage of rat hepatocarcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/18081878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18081878 |
| http://purl.uniprot.org/citations/18081878 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18081878 |
| http://purl.uniprot.org/uniprot/P49186#attribution-4CF26E8A83DCC53FD29C9D89C8C832EE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18081878 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JYS4-mappedCitation-18081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18081878 |
| http://purl.uniprot.org/uniprot/#_D4A5V8-mappedCitation-18081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18081878 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AND2-mappedCitation-18081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18081878 |
| http://purl.uniprot.org/uniprot/#_A0A8I6ANM5-mappedCitation-18081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18081878 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GCT6-mappedCitation-18081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18081878 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A503-mappedCitation-18081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18081878 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A7Z8-mappedCitation-18081878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18081878 |