| http://purl.uniprot.org/citations/18082433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18082433 | http://www.w3.org/2000/01/rdf-schema#comment | "The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Here we showed that TIM-4 is expressed on human and mouse macrophages and dendritic cells, and both TIM-4 and TIM-1 specifically bound phosphatidylserine (PS) on the surface of apoptotic cells but not any other phospholipid tested. TIM-4(+) peritoneal macrophages, TIM-1(+) kidney cells, and TIM-4- or TIM-1-transfected cells efficiently phagocytosed apoptotic cells, and phagocytosis could be blocked by TIM-4 or TIM-1 monoclonal antibodies. Mutations in the unique cavity of TIM-4 eliminated PS binding and phagocytosis. TIM-4 mAbs that blocked PS binding and phagocytosis mapped to epitopes in this binding cavity. These results show that TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2007.11.011"xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Ito S."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Kobayashi N."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Zhu B."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Freeman G.J."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Casasnovas J.M."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Kaplan G.G."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Sharpe A.H."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Umetsu D.T."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Dorfman D.M."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Nagumo H."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Dranoff G."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Butte M.J."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Dekruyff R.H."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Jinushi M."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Karisola P."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Umetsu S.E."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Chernova I."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/author | "Pena-Cruz V."xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/pages | "927-940"xsd:string |
| http://purl.uniprot.org/citations/18082433 | http://purl.uniprot.org/core/title | "TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells."xsd:string |