| http://purl.uniprot.org/citations/18082565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18082565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18082565 | http://www.w3.org/2000/01/rdf-schema#comment | "The high sequence identity observed between UNC-93B of mouse and human imply common evolutionary ancestors and a conserved function. A nonconservative point mutation in the mouse Unc93b1 gene has been associated with defective Toll-like receptor (TLR) signaling and impaired major histocompatibility complex (MHC) I and II restricted antigen responses. Like murine UNC-93B, the human homologue is predicted to form 12 transmembrane domains, and it localizes to the endoplasmic reticulum. In human beings its expression is highest in professional antigen-presenting cells such as dendritic cells and macrophages. Interestingly, UNC-93B itself is specifically induced by TLR3 signaling in monocyte-derived dendritic cells and macrophages. To study the effect of UNC-93B deficiency in TLR signaling and antigen-presentation in human beings, UNC-93B message was knocked down in monocyte-derived dendritic cells and a reduced TNFalpha production in response to TLR3 agonists was observed. In the same experiment, the achieved knockdown had no effect on an MHC II-dependent antigen response, suggesting that the reduced quantity of human UNC-93B was still capable of supporting class II antigen presentation or that UNC-93B is not required for class II antigen presentation in human antigen-presenting cells."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2007.07.007"xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2007.07.007"xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Rot A."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Rot A."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Beutler B."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Beutler B."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Zurini M."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Zurini M."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Koehn J."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Koehn J."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Korthaeuer U."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Korthaeuer U."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Jaritz M."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Jaritz M."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Huesken D."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Huesken D."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Dwertmann A."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/author | "Dwertmann A."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/name | "Hum. Immunol."xsd:string |
| http://purl.uniprot.org/citations/18082565 | http://purl.uniprot.org/core/name | "Hum. Immunol."xsd:string |