| http://purl.uniprot.org/citations/18084303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18084303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18084303 | http://www.w3.org/2000/01/rdf-schema#comment | "The heterophilic synaptic adhesion molecules neuroligins and neurexins are essential for establishing and maintaining neuronal circuits by modulating the formation and maturation of synapses. The neuroligin-neurexin adhesion is Ca2+-dependent and regulated by alternative splicing. We report a structure of the complex at a resolution of 2.4 A between the mouse neuroligin-1 (NL1) cholinesterase-like domain and the mouse neurexin-1beta (NX1beta) LNS (laminin, neurexin and sex hormone-binding globulin-like) domain. The structure revealed a delicate neuroligin-neurexin assembly mediated by a hydrophilic, Ca2+-mediated and solvent-supplemented interface, rendering it capable of being modulated by alternative splicing and other regulatory factors. Thermodynamic data supported a mechanism wherein splicing site B of NL1 acts by modulating a salt bridge at the edge of the NL1-NX1beta interface. Mapping neuroligin mutations implicated in autism indicated that most such mutations are structurally destabilizing, supporting deficient neuroligin biosynthesis and processing as a common cause for this brain disorder."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1350"xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1350"xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/author | "Focia P.J."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/author | "Focia P.J."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/author | "Shim A.H."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/author | "Shim A.H."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/pages | "50-56"xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/pages | "50-56"xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/title | "Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/title | "Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions."xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/18084303 | http://purl.uniprot.org/core/volume | "15"xsd:string |